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Mouse Anti-AP1S2 Recombinant Antibody (3B9-G5) (CBMAB-A0391-LY)

The product is antibody recognizes AP1S2. The antibody 3B9-G5 immunoassay techniques such as: sELISA, ELISA.
See all AP1S2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3B9-G5
Antibody Isotype
IgG2b, κ
Application
SELISA, ELISA

Basic Information

Immunogen
AP1S2 (AAH01117, 1 a.a. ~ 157 a.a) full-length recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
adaptor-related protein complex 1, sigma 2 subunit
Introduction
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq]
Entrez Gene ID
8905
UniProt ID
P56377
Alternative Names
DC22; MGC:1902; MRX59; SIGMA1B
Function
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Intracellular protein transport Source: InterPro
Post-Golgi vesicle-mediated transport Source: Reactome
Regulation of defense response to virus by virus Source: Reactome
Vesicle-mediated transport Source: GO_Central
Cellular Location
Golgi apparatus; Cytoplasmic vesicle membrane; Clathrin-coated pit. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Involvement in disease
Pettigrew syndrome (PGS): A syndrome characterized by mental retardation and additional highly variable features, including choreoathetosis, hydrocephalus, Dandy-Walker malformation, seizures, and iron or calcium deposition in the brain. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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