AP1S2

Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq]

Full Name

adaptor-related protein complex 1, sigma 2 subunit

Function

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Biological Process

Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Intracellular protein transport Source: InterPro
Post-Golgi vesicle-mediated transport Source: Reactome
Regulation of defense response to virus by virus Source: Reactome
Vesicle-mediated transport Source: GO_Central

Cellular Location

Golgi apparatus; Cytoplasmic vesicle membrane; Clathrin-coated pit. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Involvement in disease

Pettigrew syndrome (PGS): A syndrome characterized by mental retardation and additional highly variable features, including choreoathetosis, hydrocephalus, Dandy-Walker malformation, seizures, and iron or calcium deposition in the brain. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.