Mouse Anti-APBB2 Recombinant Antibody (CBXF-3542) (CBMAB-F2122-CQ)

Name: Mouse Anti-APBB2 Recombinant Antibody (CBXF-3542)
SKU: CBMAB-F2122-CQ
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXF-3542

Antibody Isotype

IgG1, κ

Application

ELISA, WB

Basic Information

Immunogen

APBB2 (AAH27946, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

323

UniProt ID

Q92870

Alternative Names

Amyloid Beta Precursor Protein Binding Family B Member 2; Protein Fe65-Like 1; FE65L1; FE65L; Amyloid Beta (A4) Precursor Protein-Binding, Family B, Member 2; Amyloid Beta A4 Precursor Protein-Binding Family B Member 2; Amyloid-Beta A4 Precursor Protein-Binding Family B Member 2; Fe65-Like 1; Fe65-Like;

Function

May modulate the internalization of amyloid-beta precursor protein.

Biological Process

Cell cycle arrest Source: UniProtKB
Intracellular signal transduction Source: UniProtKB
Negative regulation of cell growth Source: UniProtKB
Regulation of transcription, DNA-templated Source: GO_Central
Synapse organization Source: ARUK-UCL

Cellular Location

Nucleus; Cytoplasm; Growth cone; Lamellipodium; Membrane; Synapse

More Infomation

References

Xu, L. B., Xiong, J., Zhang, Y. H., Dai, Y., Ren, X. P., Ren, Y. J., ... & Qi, M. (2021). miR‑205‑3p promotes lung cancer progression by targeting APBB2. Molecular Medicine Reports, 24(2), 1-11.

Liu, C. C., Fang, C. P., Liu, T. H., Kuo, H. W., Liu, S. C., Wang, S. C., ... & Liu, Y. L. (2018). APBB2 is associated with amphetamine use and plasma beta-amyloids in patients receiving methadone maintenance treatment. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 83, 92-98.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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