APBB2

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Amyloid Beta Precursor Protein Binding Family B Member 2

May modulate the internalization of amyloid-beta precursor protein.

Cell cycle arrest Source: UniProtKB
Intracellular signal transduction Source: UniProtKB
Negative regulation of cell growth Source: UniProtKB
Regulation of transcription, DNA-templated Source: GO_Central
Synapse organization Source: ARUK-UCL

Nucleus; Cytoplasm; Growth cone; Lamellipodium; Membrane; Synapse