APBB2
The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Full Name
Amyloid Beta Precursor Protein Binding Family B Member 2
Function
May modulate the internalization of amyloid-beta precursor protein.
Biological Process
Cell cycle arrest Source: UniProtKB
Intracellular signal transduction Source: UniProtKB
Negative regulation of cell growth Source: UniProtKB
Regulation of transcription, DNA-templated Source: GO_Central
Synapse organization Source: ARUK-UCL
Intracellular signal transduction Source: UniProtKB
Negative regulation of cell growth Source: UniProtKB
Regulation of transcription, DNA-templated Source: GO_Central
Synapse organization Source: ARUK-UCL
Cellular Location
Nucleus; Cytoplasm; Growth cone; Lamellipodium; Membrane; Synapse
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Anti-APBB2 antibodies
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Target: APBB2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-3542
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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