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Mouse Anti-APH1A Recombinant Antibody (665404) (CBMAB-1099-CN)

This product is a mouse antibody that recognizes APH1A of human. The antibody #665404 can be used for immunoassay techniques such as: IHC.
See all APH1A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
665404
Antibody Isotype
IgG1
Application
IHC

Basic Information

Immunogen
Human APH1A synthetic peptide.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC8-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Aph-1 Homolog A, Gamma-Secretase Subunit
Introduction
This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. This is a non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein).
Entrez Gene ID
51107
UniProt ID
Q96BI3
Alternative Names
APH-1; APH-1A; CGI-78; 6530402N02Rik
Function
Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12297508, PubMed:12522139, PubMed:12763021, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Required for normal gamma-secretase assembly (PubMed:12522139, PubMed:12471034, PubMed:12763021, PubMed:19369254). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).
Biological Process
Amyloid-beta formation Source: ARUK-UCL
Amyloid fibril formation Source: Reactome
Amyloid precursor protein catabolic process Source: ARUK-UCL
Amyloid precursor protein metabolic process Source: UniProtKB
Ephrin receptor signaling pathway Source: Reactome
Membrane protein ectodomain proteolysis Source: HGNC-UCL
Membrane protein intracellular domain proteolysis Source: UniProtKB
Metanephros development Source: Ensembl
Notch receptor processing Source: ARUK-UCL
Notch receptor processing, ligand-dependent Source: Reactome
Notch signaling pathway Source: GO_Central
Positive regulation of apoptotic process Source: Reactome
Positive regulation of catalytic activity Source: HGNC-UCL
Positive regulation of endopeptidase activity Source: ARUK-UCL
Protein processing Source: HGNC-UCL
Cellular Location
Golgi stack membrane; Endoplasmic reticulum membrane. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Topology
Lumenal: 1-2 aa
Helical: 3-23 aa
Cytoplasmic: 24-31 aa
Helical: 32-52 aa
Lumenal: 53-68 aa
Helical: 69-89 aa
Cytoplasmic: 90-118 aa
Helical: 119-139 aa
Lumenal: 140-158 aa
Helical: 159-179 aa
Cytoplasmic: 180-186 aa
Helical: 187-207 aa
Lumenal: 208-213 aa
Helical: 214-234 aa
Cytoplasmic: 235-265 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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