Rabbit Anti-APOA2 Recombinant Antibody (5F7U1) (CBMAB-A3124-YC)

Name: Rabbit Anti-APOA2 Recombinant Antibody (5F7U1)
SKU: CBMAB-A3124-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

5F7U1

Application

WB, IF, IHC

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human Apolipoprotein A-II/ApoA2.

Host Species

Rabbit

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500-1:1,000
IF(ICC)	1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Apolipoprotein A2

Introduction

APOA2 is apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apol

Entrez Gene ID

Human	336
Rat	25649

UniProt ID

Human	P02652
Rat	P04638

Alternative Names

Apolipoprotein A2; Apolipoprotein A-II; Apo-AII; ApoA-II; ApoAII;

Function

May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

Biological Process

Cellular protein metabolic process Source: Reactome
Cholesterol efflux Source: BHF-UCL
Cholesterol homeostasis Source: BHF-UCL
Cholesterol metabolic process Source: GO_Central
Cholesterol transport Source: GO_Central
Chylomicron assembly Source: Reactome
Chylomicron remodeling Source: Reactome
Diacylglycerol catabolic process Source: BHF-UCL
High-density lipoprotein particle assembly Source: BHF-UCL
High-density lipoprotein particle clearance Source: BHF-UCL
High-density lipoprotein particle remodeling Source: BHF-UCL
Intermembrane lipid transfer Source: GOC
Lipoprotein metabolic process Source: GO_Central
Low-density lipoprotein particle remodeling Source: BHF-UCL
Negative regulation of cholesterol import Source: BHF-UCL
Negative regulation of cholesterol transport Source: BHF-UCL
Negative regulation of cholesterol transporter activity Source: BHF-UCL
Negative regulation of cytokine production involved in immune response Source: BHF-UCL
Negative regulation of lipase activity Source: BHF-UCL
Negative regulation of lipid catabolic process Source: BHF-UCL
Negative regulation of very-low-density lipoprotein particle remodeling Source: BHF-UCL
Peptidyl-methionine modification Source: UniProtKB
Phosphatidylcholine biosynthetic process Source: BHF-UCL
Phospholipid catabolic process Source: BHF-UCL
Phospholipid efflux Source: BHF-UCL
Positive regulation of cholesterol esterification Source: BHF-UCL
Positive regulation of interleukin-8 production Source: UniProtKB
Positive regulation of lipid catabolic process Source: BHF-UCL
Positive regulation of phagocytosis Source: UniProtKB
Post-translational protein modification Source: Reactome
Protein oxidation Source: UniProtKB
Protein stabilization Source: UniProtKB
Regulation of metabolic process Source: Reactome
Regulation of protein stability Source: BHF-UCL
Response to glucose Source: BHF-UCL
Retinoid metabolic process Source: Reactome
Reverse cholesterol transport Source: BHF-UCL
Triglyceride metabolic process Source: BHF-UCL
Triglyceride-rich lipoprotein particle remodeling Source: BHF-UCL
Viral process Source: UniProtKB-KW

Cellular Location

Secreted

PTM

Phosphorylation sites are present in the extracellular medium.
Apolipoprotein A-II is O-glycosylated.

Ramanjaneya, M., Butler, A. E., Bashir, M., Bettahi, I., Moin, A. S. M., Ahmed, L., ... & Abou-Samra, A. B. (2021). apoA2 correlates to gestational age with decreased apolipoproteins A2, C1, C3 and E in gestational diabetes. BMJ Open Diabetes Research and Care, 9(1), e001925.

Hisamatsu, T. (2021). Apolipoprotein A2 Isoforms: New Insight into the Risk of Myocardial Infarction. Journal of atherosclerosis and thrombosis, 28(5), 469-470.

Kihara, T., Yamagishi, K., Honda, K., Ikeda, A., Yatsuya, H., Saito, I., ... & JPHC Study Group. (2020). Apolipoprotein a2 isoforms in relation to the risk of myocardial infarction: A nested case-control analysis in the jphc study. Journal of atherosclerosis and thrombosis, 56218.

Sato, Y., Kobayashi, T., Nishiumi, S., Okada, A., Fujita, T., Sanuki, T., ... & Honda, K. (2020). Prospective Study Using Plasma Apolipoprotein A2-Isoforms to Screen for High-Risk Status of Pancreatic Cancer. Cancers, 12(9), 2625.

Honda, K., Katzke, V. A., Hüsing, A., Okaya, S., Shoji, H., Onidani, K., ... & Kaaks, R. (2019). CA19‐9 and apolipoprotein‐A2 isoforms as detection markers for pancreatic cancer: a prospective evaluation. International journal of cancer, 144(8), 1877-1887.

Zvintzou, E., Xepapadaki, E., Kalogeropoulou, C., Filou, S., & Kypreos, K. E. (2019). Apolipoprotein A2 Induces Structural Changes In Hdl Leading To Increased Antioxidant Activity. Atherosclerosis, 287, e225.

Kobayashi, T., Sato, Y., Nishiumi, S., Yagi, Y., Sakai, A., Shiomi, H., ... & Honda, K. (2018). Serum apolipoprotein A2 isoforms in autoimmune pancreatitis. Biochemical and biophysical research communications, 497(3), 903-907.

Sato, Y., Kobayashi, T., Nishiumi, S., Okaya, S., Yoshida, M., Kodama, Y., ... & Honda, K. (2018). Usefulness of the first screening using apolipoprotein A2 isoforms as the enrichment strategy for pancreatic cancer and its risk diseases. Annals of Oncology, 29, viii255.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

APOA2 Matched Antibody Pair (093) (CAT#: APMAB-093LY)

APOA2 Matched Antibody Pair (094) (CAT#: APMAB-094LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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