APOA2

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]

Full Name

Apolipoprotein A2

Function

May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

Biological Process

Cellular protein metabolic process Source: Reactome
Cholesterol efflux Source: BHF-UCL
Cholesterol homeostasis Source: BHF-UCL
Cholesterol metabolic process Source: GO_Central
Cholesterol transport Source: GO_Central
Chylomicron assembly Source: Reactome
Chylomicron remodeling Source: Reactome
Diacylglycerol catabolic process Source: BHF-UCL
High-density lipoprotein particle assembly Source: BHF-UCL
High-density lipoprotein particle clearance Source: BHF-UCL
High-density lipoprotein particle remodeling Source: BHF-UCL
Intermembrane lipid transfer Source: GOC
Lipoprotein metabolic process Source: GO_Central
Low-density lipoprotein particle remodeling Source: BHF-UCL
Negative regulation of cholesterol import Source: BHF-UCL
Negative regulation of cholesterol transport Source: BHF-UCL
Negative regulation of cholesterol transporter activity Source: BHF-UCL
Negative regulation of cytokine production involved in immune response Source: BHF-UCL
Negative regulation of lipase activity Source: BHF-UCL
Negative regulation of lipid catabolic process Source: BHF-UCL
Negative regulation of very-low-density lipoprotein particle remodeling Source: BHF-UCL
Peptidyl-methionine modification Source: UniProtKB
Phosphatidylcholine biosynthetic process Source: BHF-UCL
Phospholipid catabolic process Source: BHF-UCL
Phospholipid efflux Source: BHF-UCL
Positive regulation of cholesterol esterification Source: BHF-UCL
Positive regulation of interleukin-8 production Source: UniProtKB
Positive regulation of lipid catabolic process Source: BHF-UCL
Positive regulation of phagocytosis Source: UniProtKB
Post-translational protein modification Source: Reactome
Protein oxidation Source: UniProtKB
Protein stabilization Source: UniProtKB
Regulation of metabolic process Source: Reactome
Regulation of protein stability Source: BHF-UCL
Response to glucose Source: BHF-UCL
Retinoid metabolic process Source: Reactome
Reverse cholesterol transport Source: BHF-UCL
Triglyceride metabolic process Source: BHF-UCL
Triglyceride-rich lipoprotein particle remodeling Source: BHF-UCL
Viral process Source: UniProtKB-KW

Cellular Location

Secreted

PTM

Phosphorylation sites are present in the extracellular medium.
Apolipoprotein A-II is O-glycosylated.