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Mouse Anti-APOA4 Recombinant Antibody (13B35) (CBMAB-A3129-YC)

Provided herein is a Mouse monoclonal antibody against Human Apolipoprotein A4. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all APOA4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
13B35
Antibody Isotype
IgG2b, κ
Application
IHC

Basic Information

Immunogen
Human recombinant Apolipoprotein A-IV/ApoA4 protein fragment (around aa 239-371).
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC1-2 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.05% BSA
Preservative
0.05% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Apolipoprotein A4
Introduction
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted
Entrez Gene ID
UniProt ID
Alternative Names
Apolipoprotein A4; Apolipoprotein A-IV; Apo-AIV; ApoA-IV;
Function
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
Biological Process
Amyloid fibril formation Source: Reactome
Cholesterol biosynthetic process Source: GO_Central
Cholesterol efflux Source: BHF-UCL
Cholesterol homeostasis Source: BHF-UCL
Cholesterol metabolic process Source: BHF-UCL
Chylomicron assembly Source: BHF-UCL
Chylomicron remodeling Source: Reactome
High-density lipoprotein particle assembly Source: GO_Central
High-density lipoprotein particle remodeling Source: BHF-UCL
Hydrogen peroxide catabolic process Source: HGNC-UCL
Innate immune response in mucosa Source: BHF-UCL
Leukocyte cell-cell adhesion Source: BHF-UCL
Lipid catabolic process Source: BHF-UCL
Lipid homeostasis Source: BHF-UCL
Lipid transport Source: BHF-UCL
Lipoprotein metabolic process Source: GO_Central
Negative regulation of plasma lipoprotein oxidation Source: BHF-UCL
Phosphatidylcholine metabolic process Source: BHF-UCL
Phospholipid efflux Source: BHF-UCL
Positive regulation of cholesterol esterification Source: BHF-UCL
Positive regulation of fatty acid biosynthetic process Source: BHF-UCL
Positive regulation of lipid biosynthetic process Source: GO_Central
Positive regulation of lipoprotein lipase activity Source: BHF-UCL
Positive regulation of triglyceride catabolic process Source: BHF-UCL
Protein-lipid complex assembly Source: BHF-UCL
Regulation of cholesterol transport Source: BHF-UCL
Regulation of intestinal cholesterol absorption Source: GO_Central
Removal of superoxide radicals Source: HGNC-UCL
Response to lipid hydroperoxide Source: HGNC-UCL
Response to stilbenoid Source: Ensembl
Retinoid metabolic process Source: Reactome
Reverse cholesterol transport Source: BHF-UCL
Triglyceride homeostasis Source: GO_Central
Very-low-density lipoprotein particle remodeling Source: BHF-UCL
Cellular Location
Secreted
PTM
Phosphorylation sites are present in the extracellular medium.

Qu, J., Fourman, S., Fitzgerald, M., Liu, M., Nair, S., Oses-Prieto, J., ... & Bhargava, A. (2021). Low-density lipoprotein receptor-related protein 1 (LRP1) is a novel receptor for apolipoprotein A4 (APOA4) in adipose tissue. Scientific reports, 11(1), 1-14.

Li, X., Liu, X., Zhang, Y., Cheng, C., Fan, J., Zhou, J., ... & Li, Z. (2021). Hepatoprotective effect of apolipoprotein A4 against carbon tetrachloride induced acute liver injury through mediating hepatic antioxidant and inflammation response in mice. Biochemical and Biophysical Research Communications, 534, 659-665.

Li, M., Yang, X., Sun, L., Qing, Y., Hu, X., Jiang, J., ... & Wan, C. (2021). Decreased serum apolipoprotein A4 as a potential peripheral biomarker for patients with schizophrenia. Journal of Psychiatric Research, 137, 14-21.

Wang, Y., Yang, Z., Wei, Y., Li, X., & Li, S. (2021). Apolipoprotein A4 regulates the immune response in carbon tetrachloride-induced chronic liver injury in mice. International Immunopharmacology, 90, 107222.

Obinata, H., Kuo, A., Wada, Y., Swendeman, S., Liu, C. H., Blaho, V. A., ... & Hla, T. (2019). Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM-and albumin-deficient mice. Journal of lipid research, 60(11), 1912-1921.

Soukup, V., Capoun, O., Pesl, M., Vavrova, L., Sobotka, R., Levova, K., ... & Kalousova, M. (2019). The significance of calprotectin, CD147, APOA4 and DJ-1 in non-invasive detection of urinary bladder carcinoma. Neoplasma, 66(06), 1019-1023.

Kang, M., Kim, J., An, H. T., & Ko, J. (2017). Human leucine zipper protein promotes hepatic steatosis via induction of apolipoprotein A‐IV. The FASEB Journal, 31(6), 2548-2561.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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