APOA4

Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]

Apolipoprotein A4

May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

Amyloid fibril formation Source: Reactome
Cholesterol biosynthetic process Source: GO_Central
Cholesterol efflux Source: BHF-UCL
Cholesterol homeostasis Source: BHF-UCL
Cholesterol metabolic process Source: BHF-UCL
Chylomicron assembly Source: BHF-UCL
Chylomicron remodeling Source: Reactome
High-density lipoprotein particle assembly Source: GO_Central
High-density lipoprotein particle remodeling Source: BHF-UCL
Hydrogen peroxide catabolic process Source: HGNC-UCL
Innate immune response in mucosa Source: BHF-UCL
Leukocyte cell-cell adhesion Source: BHF-UCL
Lipid catabolic process Source: BHF-UCL
Lipid homeostasis Source: BHF-UCL
Lipid transport Source: BHF-UCL
Lipoprotein metabolic process Source: GO_Central
Negative regulation of plasma lipoprotein oxidation Source: BHF-UCL
Phosphatidylcholine metabolic process Source: BHF-UCL
Phospholipid efflux Source: BHF-UCL
Positive regulation of cholesterol esterification Source: BHF-UCL
Positive regulation of fatty acid biosynthetic process Source: BHF-UCL
Positive regulation of lipid biosynthetic process Source: GO_Central
Positive regulation of lipoprotein lipase activity Source: BHF-UCL
Positive regulation of triglyceride catabolic process Source: BHF-UCL
Protein-lipid complex assembly Source: BHF-UCL
Regulation of cholesterol transport Source: BHF-UCL
Regulation of intestinal cholesterol absorption Source: GO_Central
Removal of superoxide radicals Source: HGNC-UCL
Response to lipid hydroperoxide Source: HGNC-UCL
Response to stilbenoid Source: Ensembl
Retinoid metabolic process Source: Reactome
Reverse cholesterol transport Source: BHF-UCL
Triglyceride homeostasis Source: GO_Central
Very-low-density lipoprotein particle remodeling Source: BHF-UCL

Secreted

Phosphorylation sites are present in the extracellular medium.