APOA4

Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
Full Name
Apolipoprotein A4
Function
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
Biological Process
Amyloid fibril formation Source: Reactome
Cholesterol biosynthetic process Source: GO_Central
Cholesterol efflux Source: BHF-UCL
Cholesterol homeostasis Source: BHF-UCL
Cholesterol metabolic process Source: BHF-UCL
Chylomicron assembly Source: BHF-UCL
Chylomicron remodeling Source: Reactome
High-density lipoprotein particle assembly Source: GO_Central
High-density lipoprotein particle remodeling Source: BHF-UCL
Hydrogen peroxide catabolic process Source: HGNC-UCL
Innate immune response in mucosa Source: BHF-UCL
Leukocyte cell-cell adhesion Source: BHF-UCL
Lipid catabolic process Source: BHF-UCL
Lipid homeostasis Source: BHF-UCL
Lipid transport Source: BHF-UCL
Lipoprotein metabolic process Source: GO_Central
Negative regulation of plasma lipoprotein oxidation Source: BHF-UCL
Phosphatidylcholine metabolic process Source: BHF-UCL
Phospholipid efflux Source: BHF-UCL
Positive regulation of cholesterol esterification Source: BHF-UCL
Positive regulation of fatty acid biosynthetic process Source: BHF-UCL
Positive regulation of lipid biosynthetic process Source: GO_Central
Positive regulation of lipoprotein lipase activity Source: BHF-UCL
Positive regulation of triglyceride catabolic process Source: BHF-UCL
Protein-lipid complex assembly Source: BHF-UCL
Regulation of cholesterol transport Source: BHF-UCL
Regulation of intestinal cholesterol absorption Source: GO_Central
Removal of superoxide radicals Source: HGNC-UCL
Response to lipid hydroperoxide Source: HGNC-UCL
Response to stilbenoid Source: Ensembl
Retinoid metabolic process Source: Reactome
Reverse cholesterol transport Source: BHF-UCL
Triglyceride homeostasis Source: GO_Central
Very-low-density lipoprotein particle remodeling Source: BHF-UCL
Cellular Location
Secreted
PTM
Phosphorylation sites are present in the extracellular medium.
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Anti-APOA4 antibodies

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Mouse Anti-APOA4 Recombinant Antibody (4601) (CBMAB-AP382LY)

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Target: APOA4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4601
Application*: WB, P
Datasheet SDS

Mouse Anti-APOA4 Recombinant Antibody (CL0465) (CBMAB-A3133-YC)

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Target: APOA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CL0465
Application*: WB
Datasheet SDS

Mouse Anti-APOA4 Recombinant Antibody (2D1C9) (CBMAB-A3132-YC)

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Target: APOA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2D1C9
Application*: E, WB
Datasheet SDS

Mouse Anti-APOA4 Recombinant Antibody (1D6B6) (CBMAB-A3131-YC)

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Target: APOA4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Monkey
Clone: 1D6B6
Application*: WB, IP
Datasheet SDS

Mouse Anti-APOA4 Recombinant Antibody (1D4C11) (CBMAB-A3130-YC)

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Target: APOA4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D4C11
Application*: E, WB
Datasheet SDS

Mouse Anti-APOA4 Recombinant Antibody (13B35) (CBMAB-A3129-YC)

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Target: APOA4
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 13B35
Application*: IH
Datasheet SDS

Rabbit Anti-APOA4 Recombinant Antibody (13B34) (CBMAB-A3128-YC)

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Target: APOA4
Host: Rabbit
Antibody Isotype: IgG2a
Specificity: Human
Clone: 13B34
Application*: IP, WB
Datasheet SDS

Mouse Anti-APOA4 Recombinant Antibody (CBT166) (V2LY-0625-LY3746)

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Target: APOA4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT166
Application*: WB, E
Datasheet SDS

Mouse Anti-APOA4 Recombinant Antibody (CBT167) (V2LY-0625-LY3745)

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Target: APOA4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT167
Application*: WB, E
Datasheet SDS

Mouse Anti-APOA4 Recombinant Antibody (CBT3048) (V2LY-0625-LY2258)

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Target: APOA4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT3048
Application*: WB
Datasheet SDS

Mouse Anti-APOA4 Recombinant Antibody (CBT2645) (V2LY-0625-LY2256)

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Target: APOA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2645
Application*: WB
Datasheet SDS

APOA4 Matched Antibody Pair (095) (APMAB-095LY)

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Target: APOA4
Specificity: Human
Datasheet SDS

Mouse Anti-APOA4 Recombinant Antibody (CF031) (CBMAB-FT437LY)

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Target: APOA4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CF031
Application*: E, P, WB, IF, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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