Mouse Anti-APOBEC3C Recombinant Antibody (3E6) (CBMAB-A3176-YC)

Name: Mouse Anti-APOBEC3C Recombinant Antibody (3E6)
SKU: CBMAB-A3176-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3E6

Application

ELISA, IP, WB

Immunogen

APOBEC3C (NP_055323, 91-190 aa) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C

Introduction

APOBEC3C belongs to the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and function

Entrez Gene ID

27350

UniProt ID

Q9NRW3

Alternative Names

Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3C; Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3C; Phorbolin I; APOBEC1L; A3C; PBI; Apolipoprotein B Editing Enzyme Catalytic Polypeptide-Like 3C; Probable DNA DC->DU-Editing Enz

Function

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

Biological Process

Cytidine deamination Source: UniProtKB
Cytidine to uridine editing Source: GO_Central
Defense response to virus Source: GO_Central
DNA cytosine deamination Source: GO_Central
DNA demethylation Source: UniProtKB
Innate immune response Source: UniProtKB-KW
Negative regulation of single stranded viral RNA replication via double stranded DNA intermediate Source: GO_Central
Negative regulation of transposition Source: UniProtKB
Negative regulation of viral genome replication Source: UniProtKB
Viral process Source: UniProtKB-KW

Cellular Location

Cytoplasm; Nucleus

McDonnell, M. M., Crawford, K. H., Dingens, A. S., Bloom, J. D., & Emerman, M. (2020). APOBEC3C tandem domain proteins create super restriction factors against HIV-1. MBio, 11(2), e00737-20.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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