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Mouse Anti-APOBEC3C Recombinant Antibody (3E6) (CBMAB-A3176-YC)

Provided herein is a Mouse monoclonal antibody against Human Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3C. The antibody can be used for immunoassay techniques, such as ELISA, IP, WB.
See all APOBEC3C antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3E6
Antibody Isotype
IgG2a, κ
Application
ELISA, IP, WB

Basic Information

Immunogen
APOBEC3C (NP_055323, 91-190 aa) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
Introduction
APOBEC3C belongs to the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and function
Entrez Gene ID
27350
UniProt ID
Q9NRW3
Alternative Names
Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3C; Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3C; Phorbolin I; APOBEC1L; A3C; PBI; Apolipoprotein B Editing Enzyme Catalytic Polypeptide-Like 3C; Probable DNA DC->DU-Editing Enz
Function
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Biological Process
Cytidine deamination Source: UniProtKB
Cytidine to uridine editing Source: GO_Central
Defense response to virus Source: GO_Central
DNA cytosine deamination Source: GO_Central
DNA demethylation Source: UniProtKB
Innate immune response Source: UniProtKB-KW
Negative regulation of single stranded viral RNA replication via double stranded DNA intermediate Source: GO_Central
Negative regulation of transposition Source: UniProtKB
Negative regulation of viral genome replication Source: UniProtKB
Viral process Source: UniProtKB-KW
Cellular Location
Cytoplasm; Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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