Mouse Anti-APOC1 Recombinant Antibody (2E2-1A3) (CBMAB-A3192-YC)

Name: Mouse Anti-APOC1 Recombinant Antibody (2E2-1A3)
SKU: CBMAB-A3192-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2E2-1A3

Application

ELISA, WB

Immunogen

APOC1 (AAH09698, 1 a.a. ~ 83 a.a) full-length recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

apolipoprotein C-I

Introduction

APOC1 is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low de

Entrez Gene ID

341

UniProt ID

P02654

Alternative Names

Apolipoprotein C1; Apolipoprotein C-I; Apo-CI; ApoC-I; Apo-CIB; ApoC-IB;

Function

Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.

Biological Process

Cholesterol efflux Source: BHF-UCL
Chylomicron remnant clearance Source: BHF-UCL
High-density lipoprotein particle remodeling Source: BHF-UCL
Intracellular receptor signaling pathway Source: Reactome
Lipid metabolic process Source: ProtInc
Lipoprotein metabolic process Source: InterPro
Negative regulation of cholesterol transport Source: BHF-UCL
Negative regulation of fatty acid biosynthetic process Source: BHF-UCL
Negative regulation of lipid catabolic process Source: BHF-UCL
Negative regulation of lipid metabolic process Source: BHF-UCL
Negative regulation of lipoprotein lipase activity Source: BHF-UCL
Negative regulation of phosphatidylcholine catabolic process Source: BHF-UCL
Negative regulation of receptor-mediated endocytosis Source: BHF-UCL
Negative regulation of very-low-density lipoprotein particle clearance Source: BHF-UCL
Phospholipid efflux Source: BHF-UCL
Plasma lipoprotein particle remodeling Source: BHF-UCL
Positive regulation of cholesterol esterification Source: BHF-UCL
Regulation of cholesterol transport Source: BHF-UCL
Triglyceride metabolic process Source: GO_Central
Very-low-density lipoprotein particle assembly Source: BHF-UCL
Very-low-density lipoprotein particle clearance Source: BHF-UCL

Cellular Location

Secreted

Xiao, H., & Xu, Y. (2021). Overexpression of Apolipoprotein C1 (APOC1) in Clear Cell Renal Cell Carcinoma and Its Prognostic Significance. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 27, e929347-1.

Jiang, H., Tang, J. Y., Xue, D., Chen, Y. M., Wu, T. C., Zhuang, Q. F., & He, X. Z. (2021). Apolipoprotein C1 stimulates the malignant process of renal cell carcinoma via the Wnt3a signaling. Cancer cell international, 21(1), 1-12.

Wang, H. J., Ma, Y. X., Wang, A. H., Jiang, Y. S., & Jiang, X. Z. (2021). Expression of apolipoprotein C1 in clear cell renal cell carcinoma: An oncogenic gene and a prognostic marker. The Kaohsiung Journal of Medical Sciences, 37(5), 419-426.

Cui, Y., Miao, C., Liu, B., Wang, Z., & Hou, C. (2020). Apolipoprotein C1 (APOC1): a novel diagnostic and prognostic biomarker for clear cell renal cell carcinoma. Frontiers in Oncology, 10, 1436.

Shi, X., Wang, J., Dai, S., Qin, L., Zhou, J., & Chen, Y. (2020). Apolipoprotein C1 (APOC1): A Novel Diagnostic and Prognostic Biomarker for Cervical Cancer. OncoTargets and therapy, 13, 12881.

Ren, H., Chen, Z., Yang, L., Xiong, W., Yang, H., Xu, K., ... & Song, X. (2019). Apolipoprotein C1 (APOC1) promotes tumor progression via MAPK signaling pathways in colorectal cancer. Cancer management and research, 11, 4917.

Yi, J., Ren, L., Wu, J., Li, W., Zheng, X., Du, G., & Wang, J. (2019). Apolipoprotein C1 (APOC1) as a novel diagnostic and prognostic biomarker for gastric cancer. Annals of translational medicine, 7(16).

Fuior, E. V., & Gafencu, A. V. (2019). Apolipoprotein C1: its pleiotropic effects in lipid metabolism and beyond. International journal of molecular sciences, 20(23), 5939.

Su, W. P., Sun, L. N., Yang, S. L., Zhao, H., Zeng, T. Y., Wu, W. Z., & Wang, D. (2018). Apolipoprotein C1 promotes prostate cancer cell proliferation in vitro. Journal of biochemical and molecular toxicology, 32(7), e22158.

Zhang, H., Qiao, L., & Luo, G. (2018). Characterization of apolipoprotein C1 in hepatitis C virus infection and morphogenesis. Virology, 524, 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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