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Mouse Anti-APOC1 Recombinant Antibody (2E2-1A3) (CBMAB-A3192-YC)

Provided herein is a Mouse monoclonal antibody against Human Apolipoprotein C1. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all APOC1 antibodies
Published Data
Fig. 1 ApoA1, ApoA2, ApoC1, ApoE and ApoH were exogenously expressed in control and ApoE-knockdown Huh7 cells by lentiviral vectors. Expressions of the apolipoproteins were determined by immunoblotting analysis.
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Fig. 2 Immunofluorescence
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2E2-1A3
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
APOC1 (AAH09698, 1 a.a. ~ 83 a.a) full-length recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
apolipoprotein C-I
Introduction
APOC1 is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low de
Entrez Gene ID
341
UniProt ID
P02654
Alternative Names
Apolipoprotein C1; Apolipoprotein C-I; Apo-CI; ApoC-I; Apo-CIB; ApoC-IB;
Function
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
Biological Process
Cholesterol efflux Source: BHF-UCL
Chylomicron remnant clearance Source: BHF-UCL
High-density lipoprotein particle remodeling Source: BHF-UCL
Intracellular receptor signaling pathway Source: Reactome
Lipid metabolic process Source: ProtInc
Lipoprotein metabolic process Source: InterPro
Negative regulation of cholesterol transport Source: BHF-UCL
Negative regulation of fatty acid biosynthetic process Source: BHF-UCL
Negative regulation of lipid catabolic process Source: BHF-UCL
Negative regulation of lipid metabolic process Source: BHF-UCL
Negative regulation of lipoprotein lipase activity Source: BHF-UCL
Negative regulation of phosphatidylcholine catabolic process Source: BHF-UCL
Negative regulation of receptor-mediated endocytosis Source: BHF-UCL
Negative regulation of very-low-density lipoprotein particle clearance Source: BHF-UCL
Phospholipid efflux Source: BHF-UCL
Plasma lipoprotein particle remodeling Source: BHF-UCL
Positive regulation of cholesterol esterification Source: BHF-UCL
Regulation of cholesterol transport Source: BHF-UCL
Triglyceride metabolic process Source: GO_Central
Very-low-density lipoprotein particle assembly Source: BHF-UCL
Very-low-density lipoprotein particle clearance Source: BHF-UCL
Cellular Location
Secreted

Xiao, H., & Xu, Y. (2021). Overexpression of Apolipoprotein C1 (APOC1) in Clear Cell Renal Cell Carcinoma and Its Prognostic Significance. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 27, e929347-1.

Jiang, H., Tang, J. Y., Xue, D., Chen, Y. M., Wu, T. C., Zhuang, Q. F., & He, X. Z. (2021). Apolipoprotein C1 stimulates the malignant process of renal cell carcinoma via the Wnt3a signaling. Cancer cell international, 21(1), 1-12.

Wang, H. J., Ma, Y. X., Wang, A. H., Jiang, Y. S., & Jiang, X. Z. (2021). Expression of apolipoprotein C1 in clear cell renal cell carcinoma: An oncogenic gene and a prognostic marker. The Kaohsiung Journal of Medical Sciences, 37(5), 419-426.

Cui, Y., Miao, C., Liu, B., Wang, Z., & Hou, C. (2020). Apolipoprotein C1 (APOC1): a novel diagnostic and prognostic biomarker for clear cell renal cell carcinoma. Frontiers in Oncology, 10, 1436.

Shi, X., Wang, J., Dai, S., Qin, L., Zhou, J., & Chen, Y. (2020). Apolipoprotein C1 (APOC1): A Novel Diagnostic and Prognostic Biomarker for Cervical Cancer. OncoTargets and therapy, 13, 12881.

Ren, H., Chen, Z., Yang, L., Xiong, W., Yang, H., Xu, K., ... & Song, X. (2019). Apolipoprotein C1 (APOC1) promotes tumor progression via MAPK signaling pathways in colorectal cancer. Cancer management and research, 11, 4917.

Yi, J., Ren, L., Wu, J., Li, W., Zheng, X., Du, G., & Wang, J. (2019). Apolipoprotein C1 (APOC1) as a novel diagnostic and prognostic biomarker for gastric cancer. Annals of translational medicine, 7(16).

Fuior, E. V., & Gafencu, A. V. (2019). Apolipoprotein C1: its pleiotropic effects in lipid metabolism and beyond. International journal of molecular sciences, 20(23), 5939.

Su, W. P., Sun, L. N., Yang, S. L., Zhao, H., Zeng, T. Y., Wu, W. Z., & Wang, D. (2018). Apolipoprotein C1 promotes prostate cancer cell proliferation in vitro. Journal of biochemical and molecular toxicology, 32(7), e22158.

Zhang, H., Qiao, L., & Luo, G. (2018). Characterization of apolipoprotein C1 in hepatitis C virus infection and morphogenesis. Virology, 524, 1-9.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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