APOC1

The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq]

Full Name

apolipoprotein C-I

Function

Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.

Biological Process

Cholesterol efflux Source: BHF-UCL
Chylomicron remnant clearance Source: BHF-UCL
High-density lipoprotein particle remodeling Source: BHF-UCL
Intracellular receptor signaling pathway Source: Reactome
Lipid metabolic process Source: ProtInc
Lipoprotein metabolic process Source: InterPro
Negative regulation of cholesterol transport Source: BHF-UCL
Negative regulation of fatty acid biosynthetic process Source: BHF-UCL
Negative regulation of lipid catabolic process Source: BHF-UCL
Negative regulation of lipid metabolic process Source: BHF-UCL
Negative regulation of lipoprotein lipase activity Source: BHF-UCL
Negative regulation of phosphatidylcholine catabolic process Source: BHF-UCL
Negative regulation of receptor-mediated endocytosis Source: BHF-UCL
Negative regulation of very-low-density lipoprotein particle clearance Source: BHF-UCL
Phospholipid efflux Source: BHF-UCL
Plasma lipoprotein particle remodeling Source: BHF-UCL
Positive regulation of cholesterol esterification Source: BHF-UCL
Regulation of cholesterol transport Source: BHF-UCL
Triglyceride metabolic process Source: GO_Central
Very-low-density lipoprotein particle assembly Source: BHF-UCL
Very-low-density lipoprotein particle clearance Source: BHF-UCL

Cellular Location

Secreted