Mouse Anti-APOC2 Recombinant Antibody (3E4) (CBMAB-A3194-YC)

apolipoprotein C-II

APOC2 is a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides a

Apolipoprotein C2; Apolipoprotein C-II; APO-CII; APOC-II; APC2;

Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.

Cholesterol efflux Source: BHF-UCL
Cholesterol homeostasis Source: BHF-UCL
Chylomicron assembly Source: Reactome
Chylomicron remnant clearance Source: BHF-UCL
Chylomicron remodeling Source: Reactome
High-density lipoprotein particle clearance Source: BHF-UCL
High-density lipoprotein particle remodeling Source: Reactome
Intracellular receptor signaling pathway Source: Reactome
Lipid catabolic process Source: UniProtKB-KW
Negative regulation of cholesterol transport Source: BHF-UCL
Negative regulation of lipid metabolic process Source: BHF-UCL
Negative regulation of receptor-mediated endocytosis Source: BHF-UCL
Negative regulation of very-low-density lipoprotein particle clearance Source: BHF-UCL
Phospholipid efflux Source: BHF-UCL
Positive regulation of fatty acid biosynthetic process Source: BHF-UCL
Positive regulation of lipoprotein lipase activity Source: BHF-UCL
Positive regulation of phospholipase activity Source: BHF-UCL
Positive regulation of phospholipid catabolic process Source: BHF-UCL
Positive regulation of triglyceride catabolic process Source: BHF-UCL
Positive regulation of very-low-density lipoprotein particle remodeling Source: BHF-UCL
Retinoid metabolic process Source: Reactome
Reverse cholesterol transport Source: BHF-UCL
Triglyceride homeostasis Source: BHF-UCL
Triglyceride-rich lipoprotein particle remodeling Source: BHF-UCL
Very-low-density lipoprotein particle remodeling Source: BHF-UCL

Secreted

Hyperlipoproteinemia 1B (HLPP1B): Autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.

Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.