Human APOC2 ELISA Kit (V2LY-0626-LY5610)

Name: Human APOC2 ELISA Kit
SKU: V2LY-0626-LY5610
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0097 ng/mL

Detection Range

0.02-3.8 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

11.3 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

apolipoprotein C-II

Function

Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.

Biological Process

Cholesterol efflux Source: BHF-UCL
Cholesterol homeostasis Source: BHF-UCL
Chylomicron assembly Source: Reactome
Chylomicron remnant clearance Source: BHF-UCL
Chylomicron remodeling Source: Reactome
High-density lipoprotein particle clearance Source: BHF-UCL
High-density lipoprotein particle remodeling Source: Reactome
Intracellular receptor signaling pathway Source: Reactome
Lipid catabolic process Source: UniProtKB-KW
Negative regulation of cholesterol transport Source: BHF-UCL
Negative regulation of lipid metabolic process Source: BHF-UCL
Negative regulation of receptor-mediated endocytosis Source: BHF-UCL
Negative regulation of very-low-density lipoprotein particle clearance Source: BHF-UCL
Phospholipid efflux Source: BHF-UCL
Positive regulation of fatty acid biosynthetic process Source: BHF-UCL
Positive regulation of lipoprotein lipase activity Source: BHF-UCL
Positive regulation of phospholipase activity Source: BHF-UCL
Positive regulation of phospholipid catabolic process Source: BHF-UCL
Positive regulation of triglyceride catabolic process Source: BHF-UCL
Positive regulation of very-low-density lipoprotein particle remodeling Source: BHF-UCL
Retinoid metabolic process Source: Reactome
Reverse cholesterol transport Source: BHF-UCL
Triglyceride homeostasis Source: BHF-UCL
Triglyceride-rich lipoprotein particle remodeling Source: BHF-UCL
Very-low-density lipoprotein particle remodeling Source: BHF-UCL

Cellular Location

Secreted

Involvement in disease

Hyperlipoproteinemia 1B (HLPP1B): Autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.

PTM

Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.

Liu, Y., Meng, Y., Zhang, T., & Alachkar, H. (2021). Deregulation of apolipoprotein C2 gene in cancer: A potential metabolic vulnerability. Clinical and Translational Medicine, 11(6).

Xenoulis, P. G., Tate, N. M., Bishop, M. A., Steiner, J. M., Suchodolski, J. S., & Furrow, E. (2020). Sequence analysis of the coding regions of the apolipoprotein C2 (APOC2) gene in Miniature Schnauzers with idiopathic hypertriglyceridemia. The Veterinary Journal, 265, 105559.

Zhang, T., Yang, J., Vaikari, V. P., Beckford, J. S., Wu, S., Akhtari, M., & Alachkar, H. (2020). Apolipoprotein C2-CD36 promotes leukemia growth and presents a targetable axis in acute myeloid leukemia. Blood cancer discovery, 1(2), 198.

Li, L., Xu, W., Fu, X., Huang, Y., Wen, Y., Xu, Q., ... & Lv, Z. (2020). Blood miR-1275 is associated with risk of ischemic stroke and inhibits macrophage foam cell formation by targeting ApoC2 gene. Gene, 731, 144364.

Lizunov, A. V., Okunevich, I. V., Pyotrovskiy, L. B., & Shabanov, P. D. (2020). Effects of kramizole on the expression of apo AI, APOC2, and SR-B1 genes in the hypercholesterol diet-induced rat model. Atherosclerosis, 315, e186-e187.

Yang, C., Tian, W., Ma, S., Guo, M., Lin, X., Gao, F., ... & Xian, X. (2020). AAV-Mediated ApoC2 gene therapy: reversal of severe hypertriglyceridemia and rescue of neonatal death in ApoC2-deficient hamsters. Molecular Therapy-Methods & Clinical Development, 18, 692-701.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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