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Rabbit Anti-APOD Recombinant Antibody (68) (CBMAB-AP394LY)

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Datasheet
SDS
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rabbit
Clone
68
Application
IHC, WB
Immunogen
A synthesized peptide derived from human Apolipoprotein D.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000
IHC1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 150mM NaCl, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Apolipoprotein D
Introduction
This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism. [provided by RefSeq, Aug 2008]
Entrez Gene ID
347
UniProt ID
P05090
Alternative Names
Apolipoprotein D; Apo-D; ApoD;
Function
APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.
Biological Process
Aging Source: UniProtKB
Angiogenesis Source: UniProtKB
Brain development Source: UniProtKB
Glucose metabolic process Source: UniProtKB
Intracellular receptor signaling pathway Source: Reactome
Lipid metabolic process Source: UniProtKB
Negative regulation of cytokine production involved in inflammatory response Source: UniProtKB
Negative regulation of focal adhesion assembly Source: UniProtKB
Negative regulation of lipoprotein lipid oxidation Source: UniProtKB
Negative regulation of monocyte chemotactic protein-1 production Source: UniProtKB
Negative regulation of platelet-derived growth factor receptor signaling pathway Source: UniProtKB
Negative regulation of protein import into nucleus Source: UniProtKB
Negative regulation of smooth muscle cell-matrix adhesion Source: UniProtKB
Negative regulation of smooth muscle cell proliferation Source: UniProtKB
Negative regulation of T cell migration Source: UniProtKB
Peripheral nervous system axon regeneration Source: UniProtKB
Response to axon injury Source: UniProtKB
Response to drug Source: UniProtKB
Response to reactive oxygen species Source: UniProtKB
Tissue regeneration Source: UniProtKB
Cellular Location
Secreted
PTM
N-glycosylatd. N-glycan heterogeneity at Asn-65: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); at Asn-98: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), dHex1Hex6HexNAc5 (minor) and dHex1Hex7HexNAc6 (minor).

Kielkopf, C. S., Whitten, A. E., Garner, B., & Brown, S. H. (2021). Small angle X-ray scattering analysis of ligand-bound forms of tetrameric apolipoprotein-D. Bioscience Reports, 41(1), BSR20201423.

Henri, P., & Rumeau, D. (2021). Ectopic expression of human apolipoprotein D in Arabidopsis plants lacking chloroplastic lipocalin partially rescues sensitivity to drought and oxidative stress. Plant Physiology and Biochemistry, 158, 265-274.

Pascua-Maestro, R., Corraliza-Gomez, M., Fadrique-Rojo, C., Ledesma, M. D., Schuchman, E. H., Sanchez, D., & Ganfornina, M. D. (2020). Apolipoprotein D-mediated preservation of lysosomal function promotes cell survival and delays motor impairment in Niemann-Pick type A disease. Neurobiology of Disease, 144, 105046.

Jankovic‐Karasoulos, T., Bianco‐Miotto, T., Butler, M. S., Butler, L. M., McNeil, C. M., O’Toole, S. A., ... & Ricciardelli, C. (2020). Elevated levels of tumour apolipoprotein D independently predict poor outcome in breast cancer patients. Histopathology, 76(7), 976-987.

Kuiperij, H. B., Hondius, D. C., Kersten, I., Versleijen, A. A. M., Rozemuller, A. J. M., Greenberg, S. M., ... & Verbeek, M. M. (2020). Apolipoprotein D: a potential biomarker for cerebral amyloid angiopathy. Neuropathology and applied neurobiology, 46(5), 431-440.

Bhatia, S., Kim, W. S., Shepherd, C. E., & Halliday, G. M. (2019). Apolipoprotein D upregulation in Alzheimer’s disease but not frontotemporal dementia. Journal of Molecular Neuroscience, 67(1), 125-132.

Yu, R. H., Zhang, X. Y., Xu, W., Li, Z. K., & Zhu, X. D. (2020). Apolipoprotein D alleviates glucocorticoid-induced osteogenesis suppression in bone marrow mesenchymal stem cells via the PI3K/Akt pathway. Journal of Orthopaedic Surgery and Research, 15(1), 1-8.

Salami, M., Bandegi, A. R., Sameni, H. R., Vafaei, A. A., & Pakdel, A. (2019). Hippocampal up-regulation of apolipoprotein D in a rat model of maternal hypo-and hyperthyroidism: implication of oxidative stress. Neurochemical research, 44(9), 2190-2201.

Waldner, A., Dassati, S., Redl, B., Smania, N., & Gandolfi, M. (2018). Apolipoprotein D concentration in human plasma during aging and in Parkinson’s disease: a cross-sectional study. Parkinson’s Disease, 2018.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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