APOD

This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism. [provided by RefSeq, Aug 2008]

Full Name

Apolipoprotein D

Function

APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.

Biological Process

Aging Source: UniProtKB
Angiogenesis Source: UniProtKB
Brain development Source: UniProtKB
Glucose metabolic process Source: UniProtKB
Intracellular receptor signaling pathway Source: Reactome
Lipid metabolic process Source: UniProtKB
Negative regulation of cytokine production involved in inflammatory response Source: UniProtKB
Negative regulation of focal adhesion assembly Source: UniProtKB
Negative regulation of lipoprotein lipid oxidation Source: UniProtKB
Negative regulation of monocyte chemotactic protein-1 production Source: UniProtKB
Negative regulation of platelet-derived growth factor receptor signaling pathway Source: UniProtKB
Negative regulation of protein import into nucleus Source: UniProtKB
Negative regulation of smooth muscle cell-matrix adhesion Source: UniProtKB
Negative regulation of smooth muscle cell proliferation Source: UniProtKB
Negative regulation of T cell migration Source: UniProtKB
Peripheral nervous system axon regeneration Source: UniProtKB
Response to axon injury Source: UniProtKB
Response to drug Source: UniProtKB
Response to reactive oxygen species Source: UniProtKB
Tissue regeneration Source: UniProtKB

Cellular Location

Secreted

PTM

N-glycosylatd. N-glycan heterogeneity at Asn-65: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); at Asn-98: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), dHex1Hex6HexNAc5 (minor) and dHex1Hex7HexNAc6 (minor).