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Mouse Anti-APOOL Recombinant Antibody (G-6) (CBMAB-1107-CN)

This product is a mouse antibody that recognizes APOOL of human. The antibody G-6 can be used for immunoassay techniques such as: WB, ELISA, IF, IHC-P, IP.
See all APOOL antibodies
Published Data
Mouse Anti-APOOL Recombinant Antibody (G-6) in IP
CoIP assay showing stronger GR80-Mic27 interaction compared with GR80-Mic10 (Minos1) interaction in HEK293T cells. ...View More
Li, S., Wu, Z., Li, Y., Tantray, I., De Stefani, D., Mattarei, A., ... & Lu, B. (2020). Altered MICOS morphology and mitochondrial ion homeostasis contribute to poly (GR) toxicity associated with C9-ALS/FTD. Cell reports, 32(5).

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
G-6
Antibody Isotype
IgG2a, κ
Application
WB, ELISA, IF, IHC-P, IP

Basic Information

Immunogen
Amino acids 239-262 near the C-terminus of apoOL of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:30-1:3,000
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Apolipoprotein O Like
Introduction
This gene encodes a protein which contains an apolipoprotein O superfamily domain. This domain is found on proteins in circulating lipoprotein complexes. Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. The proein specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. This protein plays a crucial role in crista junction formation and mitochondrial function.
Entrez Gene ID
Human139322
Mouse68117
Rat317191
UniProt ID
HumanQ6UXV4
MouseQ78IK4
RatQ5U1W6
Alternative Names
Mic27; CXorf33; FAM121A; UNQ8193
Function
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:23704930), (PubMed:25764979).
Biological Process
Cristae formation Source: GO_Central
Inner mitochondrial membrane organization Source: UniProtKB
Platelet degranulation Source: Reactome
Cellular Location
Mitochondrion inner membrane; Mitochondrion
Topology
Mitochondrial intermembrane: 28-110 aa
Helical: 111-129 aa
Mitochondrial matrix: 130-137 aa
Helical: 138-155 aa
Mitochondrial intermembrane: 156-268 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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