APOOL

This gene encodes a protein which contains an apolipoprotein O superfamily domain. This domain is found on proteins in circulating lipoprotein complexes. [provided by RefSeq, Sep 2011]

Full Name

Apolipoprotein O Like

Function

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:23704930), (PubMed:25764979).

Biological Process

Cristae formation Source: GO_Central
Inner mitochondrial membrane organization Source: UniProtKB
Platelet degranulation Source: Reactome

Cellular Location

Mitochondrion inner membrane; Mitochondrion

Topology

Mitochondrial intermembrane: 28-110 aa
Helical: 111-129 aa
Mitochondrial matrix: 130-137 aa
Helical: 138-155 aa
Mitochondrial intermembrane: 156-268 aa