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Mouse Anti-ARCN1 Recombinant Antibody (CBFYC-0568) (CBMAB-C0622-FY)

This product is mouse antibody that recognizes ARCN1. The antibody CBFYC-0568 can be used for immunoassay techniques such as: WB.
See all ARCN1 antibodies
Published Data
Mouse Anti-ARCN1 Recombinant Antibody (CBFYC-0568) CBMAB-C0622-FY in Immunoblot
Immunoblot analysis of THP-1 cells after CRISPR/Cas9-mediated genetic deletion of COPI-subunit proteins COPA, COPG1, COPD and COPE following treatment with STING inhibitor H-151 (2.5 µM). Results are shown as a representative of n = 3 independent repeats. ...View More
Steiner, A., Hrovat-Schaale, K., Prigione, I., Yu, C. H., Laohamonthonkul, P., Harapas, C. R., ... & Masters, S. L. (2022). Deficiency in coatomer complex I causes aberrant activation of STING signalling. Nature communications, 13(1), 2321.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYC-0568
Antibody Isotype
IgG2a, κ
Application
ELISA, WB, IF, IP

Basic Information

Immunogen
Amino acids 254-511 mapping at the C-terminus of COPD of human origin.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Archain 1
Introduction
This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or trafficking.
Entrez Gene ID
Human372
Mouse213827
Rat300674
UniProt ID
HumanP48444
MouseQ5XJY5
RatQ66H80
Alternative Names
Archain 1; Coatomer Protein Complex, Subunit Delta; Delta-Coat Protein; Delta-COP; COPD; Archain Vesicle Transport Protein 1
Function
Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
Biological Process
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
Golgi localization Source: GO_Central
Intracellular protein transport Source: ProtInc
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central
Cellular Location
Golgi apparatus membrane; Cytoplasm; COPI-coated vesicle membrane. The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Involvement in disease
Short stature, rhizomelic, with microcephaly, micrognathia, and developmental delay (SRMMD): The disease is caused by variants affecting the gene represented in this entry. the skeletal phenotype, that characterizes this disorder, may be due to defective type I collagen transport and reduction of collagen secretion. A disorder characterized by facial dysmorphism, severe micrognathia, microcephaly, rhizomelic short stature, and mild developmental delay.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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