Mouse Anti-ARID1B Recombinant Antibody (2D2) (CBMAB-A3545-YC)

AT-Rich Interaction Domain 1B

ARID1B is an AT-rich DNA interacting domain-containing protein. ARID1B is a component of the SWI/SNF chromatin remodeling complex and may play a role in cell-cycle activation. The protein encoded by this locus is similar to AT-rich interactive domain-cont

AT-Rich Interaction Domain 1B; AT Rich Interactive Domain 1B (SWI1-Like); ARID Domain-Containing Protein 1B; BRG1-Associated Factor 250b; BAF250B; P250R; DAN15; OSA2; AT-Rich Interactive Domain-Containing Protein 1B; BRG1-Binding Protein HELD/OSA1; BRG1-B

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Binds DNA non-specifically (PubMed:14982958, PubMed:15170388).

ATP-dependent chromatin remodeling Source: GO_Central
Cellular response to angiotensin Source: Ensembl
Chromatin-mediated maintenance of transcription Source: UniProtKB
Nervous system development Source: UniProtKB-KW
Positive regulation of transcription, DNA-templated Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to ischemia Source: Ensembl

Nucleus

Coffin-Siris syndrome 1 (CSS1): A form of Coffin-Siris syndrome, a congenital multiple malformation syndrome with broad phenotypic and genetic variability. Cardinal features are intellectual disability, coarse facial features, hypertrichosis, and hypoplastic or absent fifth digit nails or phalanges. Additional features include malformations of the cardiac, gastrointestinal, genitourinary, and/or central nervous systems. Sucking/feeding difficulties, poor growth, ophthalmologic abnormalities, hearing impairment, and spinal anomalies are common findings. Both autosomal dominant and autosomal recessive inheritance patterns have been reported.