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Mouse Anti-ARPC4 Recombinant Antibody (1E5) (CBMAB-A3656-YC)

Provided herein is a Mouse monoclonal antibody against Human Actin Related Protein 2/3 Complex Subunit 4. The antibody can be used for immunoassay techniques, such as ELISA.
See all ARPC4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E5
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa1-110 from ARPC4 (NP_005709) with GST tag.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
actin related protein 2/3 complex, subunit 4, 20kDa
Introduction
ARPC4 is one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. x is the p20 subunit, which is necessary for actin nucleation and high-affinity
Entrez Gene ID
Human10093
Mouse68089
UniProt ID
HumanP59998
MouseP59999
Alternative Names
Actin Related Protein 2/3 Complex Subunit 4; Actin Related Protein 2/3 Complex, Subunit 4 (20 KD); Arp2/3 Protein Complex Subunit P20; Arp2/3 Complex 20 KDa Subunit; P20-ARC; ARC20; Actin Related Protein 2/3 Complex, Subunit 4, 20kDa; Actin Related Protei
Function
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079).
The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079).
In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947).
The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Biological Process
Actin filament polymerization Source: InterPro
Actin nucleation Source: UniProtKB
Arp2/3 complex-mediated actin nucleation Source: FlyBase
Ephrin receptor signaling pathway Source: Reactome
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
Membrane organization Source: Reactome
Cellular Location
Cytoskeleton; Nucleus; Cell projection
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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