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Rabbit Anti-ARRB2 Recombinant Antibody (C16D9) (CBMAB-A3673-YC)


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Published Data
Rabbit Anti-ARRB2 Recombinant Antibody (C16D9) CBMAB-A3673-YC in IHC
Rabbit Anti-ARRB2 Recombinant Antibody (C16D9) CBMAB-A3673-YC in IHC
Localization of G protein-coupled receptor kinase 2 (GRK2), β-arrestin2, and 8-hydroxy2'deoxyguanosine (8-OHdG) in two patients with takotsubo syndrome who underwent endomyocardial biopsy in both the acute and recovery phases. Micrographs showing immunofuorescence stainings of GRK2 and β-arrestin2, and immunohistochemical staining of 8-OHdG in the acute and recovery phases. Arrowheads (yellow) indicate positive signals for GRK2 and β-arrestin2 on the cell membrane, and Arrowheads (red) indicate 8-OHdG-positive nuclei. ...View More
Nakano, T., Onoue, K., Nakada, Y., Nakagawa, H., Kumazawa, T., Ueda, T., ... & Saito, Y. (2018). Alteration of β-adrenoceptor signaling in left ventricle of acute phase takotsubo syndrome: a human study. Scientific reports, 8(1), 12731.
Rabbit Anti-ARRB2 Recombinant Antibody (C16D9) CBMAB-A3673-YC in WB
Rabbit Anti-ARRB2 Recombinant Antibody (C16D9) CBMAB-A3673-YC in WB
Representative blots from each protein target are shown, with the treatment and molecular weight markers indicated. ...View More
Lei, W., Mullen, N., McCarthy, S., Brann, C., Richard, P., Cormier, J., ... & Streicher, J. M. (2017). Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain. Journal of Biological Chemistry, 292(25), 10414-10428.

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
C16D9
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Immunogen
Recombinant human β-arrestin 2.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IP1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10mM HEPES, pH 7.5, 0.15M NaCl, 0.1mg/mL BSA, 50% Glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ARRB2
Introduction
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory si
Entrez Gene ID
Human409
Mouse216869
Rat25388
Monkey709399
UniProt ID
HumanP32121
MouseQ91YI4
RatP29067
MonkeyH2QBY1
Alternative Names
Arrestin Beta 2; Non-Visual Arrestin-3; Arrestin 3; ARR2; ARB2; Arrestin, Beta 2; Beta-Arrestin-2; Arrestin Beta-2; BARR2;
Cellular Location
Cytoplasm; Nucleus; Cell membrane; Clathrin-coated pit; Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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