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Mouse Anti-ARRB2 Recombinant Antibody (B4) (CBMAB-A3674-YC)


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Published Data
Mouse Anti-ARRB2 Recombinant Antibody (B4) CBMAB-A3674-YC in IP
Mouse Anti-ARRB2 Recombinant Antibody (B4) CBMAB-A3674-YC in IP
IP assays for studying GPR120-β-arrestin 2 interactions in WT and AMPKα2−/− VSMCs. All data shown represent one of two separate experiments. Quantification of western blots was performed using ImagePro plus software, distinctly from loading controls. Data are presented as the mean ± s.e.m. p value by two-sided Student's ttests. ...View More
Yan, C. H., Liu, H. W., Tian, X. X., Li, J., Ding, Y., Li, Y., ... & Han, Y. L. (2022). AMPKα2 controls the anti-atherosclerotic effects of fish oils by modulating the SUMOylation of GPR120. Nature Communications, 13(1), 7721.
Mouse Anti-ARRB2 Recombinant Antibody (B4) CBMAB-A3674-YC in WB
Mouse Anti-ARRB2 Recombinant Antibody (B4) CBMAB-A3674-YC in WB
Western blot analysis of ARRB2 protein levels in the retina. ...View More
Harun-Or-Rashid, M., & Inman, D. M. (2018). Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma. Journal of neuroinflammation, 15(1), 1-15.
Mouse Anti-ARRB2 Recombinant Antibody (B4) CBMAB-A3674-YC in Immunoblot
Mouse Anti-ARRB2 Recombinant Antibody (B4) CBMAB-A3674-YC in Immunoblot
Immunoblotting (IB) analysis of established upstream regulators of canonical Wnt signaling, including APC (adenomatosis polyposis coli protein), ATDC (ataxia-telangiectasia group D-associated protein), Axin, β-arrestin, β-TrCP (β-transducin repeat), CK-1α (casein kinase 1α), Dvl-1, Dvl-2, Dvl-3, GSK-3β (glycogen synthase kinase-3β), PAR-1 (protease activated receptor 1), PP2A (protein phosphatase 2A) and tankyrase, in control- or ASPMKD PC-3 cells. Right, the fold of reduction in the protein abundance level of the indicated Wnt regulator in control- vs. ASPM-KD PC-3 cells. ...View More
Pai, V. C., Hsu, C. C., Chan, T. S., Liao, W. Y., Chuu, C. P., Chen, W. Y., ... & Tsai, K. K. (2019). ASPM promotes prostate cancer stemness and progression by augmenting Wnt− Dvl-3− β-catenin signaling. Oncogene, 38(8), 1340-1353.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
B4
Antibody Isotype
IgG2a, κ
Application
ELISA, ICC, IF, WB, IHC-P

Basic Information

Immunogen
Amino acids 385-408 at the C-terminus of β-Arrestin-2 of human origin.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
IHC-P1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ARRB2
Introduction
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory si
Entrez Gene ID
394099
UniProt ID
Q7T2D2
Alternative Names
Arrestin Beta 2; Non-Visual Arrestin-3; Arrestin 3; ARR2; ARB2; Arrestin, Beta 2; Beta-Arrestin-2; Arrestin Beta-2; BARR2;
Cellular Location
Cytoplasm; Nucleus; Cell membrane; Clathrin-coated pit; Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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