Mouse Anti-ASCL1 Recombinant Antibody (3D3) (CBMAB-A0533-LY)

achaete-scute complex homolog 1 (Drosophila)

This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq]

ASH1; HASH1; MASH1; bHLHa46

Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Involved in the regulation of neuroendocrine cell development in the glandular stomach (By similarity).

Adrenal chromaffin cell differentiation Source: Ensembl
Carotid body glomus cell differentiation Source: Ensembl
Cell maturation Source: Ensembl
Cellular response to magnetism Source: Ensembl
Central nervous system neuron development Source: Ensembl
Cerebral cortex development Source: Ensembl
Cerebral cortex GABAergic interneuron differentiation Source: UniProtKB
Commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
Heart development Source: Ensembl
Lung epithelial cell differentiation Source: UniProtKB
Lung neuroendocrine cell differentiation Source: Ensembl
Musculoskeletal movement, spinal reflex action Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of neuron differentiation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Neuroblast fate determination Source: Ensembl
Neuroblast proliferation Source: Ensembl
Neurogenesis Source: UniProtKB
Neuron development Source: UniProtKB
Neuron differentiation Source: UniProtKB
Neuron fate commitment Source: UniProtKB
Neuron fate specification Source: UniProtKB
Neuron migration Source: Ensembl
Noradrenergic neuron development Source: UniProtKB
Noradrenergic neuron fate commitment Source: UniProtKB
Notch signaling pathway Source: UniProtKB
Olfactory pit development Source: Ensembl
Oligodendrocyte development Source: Ensembl
Positive regulation of cell cycle Source: Ensembl
Positive regulation of neural precursor cell proliferation Source: Ensembl
Positive regulation of neurogenesis Source: Ensembl
Positive regulation of neuron apoptotic process Source: Ensembl
Positive regulation of neuron differentiation Source: UniProtKB
Positive regulation of Notch signaling pathway Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of epithelial cell differentiation Source: Ensembl
Regulation of gene expression Source: UniProtKB
Regulation of mitotic cell cycle Source: Ensembl
Regulation of neurogenesis Source: GO_Central
Regulation of timing of subpallium neuron differentiation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to epidermal growth factor Source: Ensembl
Response to folic acid Source: Ensembl
Response to lithium ion Source: Ensembl
Response to retinoic acid Source: UniProtKB
Sensory organ development Source: GO_Central
Spinal cord association neuron differentiation Source: Ensembl
Spinal cord oligodendrocyte cell fate specification Source: Ensembl
Stomach neuroendocrine cell differentiation Source: Ensembl
Subpallium neuron fate commitment Source: Ensembl
Sympathetic ganglion development Source: UniProtKB
Sympathetic nervous system development Source: UniProtKB
Ventral spinal cord interneuron fate commitment Source: UniProtKB
Vestibular nucleus development Source: Ensembl

Nucleus