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Mouse Anti-ASH1L Recombinant Antibody (4G12) (CBMAB-A3772-YC)

Provided herein is a Mouse monoclonal antibody against Human ASH1 Like Histone Lysine Methyltransferase. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all ASH1L antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4G12
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
ASH1L (NP_060959. 1, 2859-2967 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ash1 (absent, small, or homeotic)-like (Drosophila)
Introduction
ASH1L is a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions.
Entrez Gene ID
55870
UniProt ID
Q9NR48
Alternative Names
ASH1 Like Histone Lysine Methyltransferase; Absent Small And Homeotic Disks Protein 1 Homolog; Lysine N-Methyltransferase 2H; ASH1-Like Protein; EC 2.1.1.43; KMT2H; Ash1 (Absent, Small, Or Homeotic)-Like (Drosophila); Probable Histone-Lysine N-Methyltrans
Function
Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497).
Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity).
The physiological significance of the H3K9me1 activity is unclear (By similarity).
Biological Process
Decidualization Source: Ensembl
Flagellated sperm motility Source: Ensembl
Histone H3-K36 dimethylation Source: HGNC
Negative regulation of acute inflammatory response Source: Ensembl
Negative regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
Negative regulation of MAPK cascade Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Post-embryonic development Source: Ensembl
Single fertilization Source: Ensembl
Skeletal system development Source: Ensembl
Tarsal gland development Source: Ensembl
Uterine gland development Source: Ensembl
Uterus morphogenesis Source: Ensembl
Cellular Location
Nucleus; Tight junction; Chromosome. The relevance of tight junction localization is however unclear.
Involvement in disease
Mental retardation, autosomal dominant 52 (MRD52): A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
PTM
Methylated at Gln-1220 by N6AMT1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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