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Mouse Anti-ATAD2 Recombinant Antibody (1F12) (CBMAB-0136-YC)

Provided herein are mouse monoclonal antibodies against Human ATAD2. The antibody clone 1F12 can be used for immunoassay techniques, such as IP, WB and MA.
See all ATAD2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F12
Antibody Isotype
IgG2b
Application
ICC, IF

Basic Information

Immunogen
Human ATAD2 synthetic peptide.
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)8-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATAD2
Introduction
ATPase Family, AAA Domain Containing 2 (ATAD2) is a protein containing two AAA domains, as well as a bromodomain. Diseases associated with ATAD2 include Charcot-Marie-Tooth Disease, Type 1E. Among its related pathways are transcriptional regulation by the AP-2 (TFAP2) family of transcription factors and gene expression. This gene include chromatin binding and histone binding. An important paralog of this gene is ATAD2B.
Entrez Gene ID
29028
UniProt ID
Q6PL18
Alternative Names
ATPase Family, AAA Domain Containing 2; AAA Nuclear Coregulator Cancer-Associated Protein; ANCCA; EC 3.6.1.3; PRO2000; CT137
Function
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.
Biological Process
Chromatin organization Source: InterPro
Negative regulation of chromatin silencing Source: GO_Central
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription by RNA polymerase II Source: Reactome
Cellular Location
Nucleus

Zhou, L., Yang, C., Zhang, N., Zhang, X., Zhao, T., & Yu, J. (2020). Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2. Biomedicine & Pharmacotherapy, 125, 109964.

Liu, Q., Liu, H., Li, L., Dong, X., Ru, X., Fan, X., ... & Liu, J. (2020). ATAD2 predicts poor outcomes in patients with ovarian cancer and is a marker of proliferation. International journal of oncology, 56(1), 219-231.

Potluri, L. B., Talluri, S., Buon, L., Samur, M. K., Aktas-Samur, A., Shi, J., ... & Munshi, N. C. (2020). Atpase Family AAA Domain-Containing Protein 2 (ATAD2) As a Novel Target in Multiple Myeloma. Blood, 136, 50.

Wang, X. L., Wang, S., Wu, Z. Z., Yang, Q. C., Li, H., Xiong, H. G., ... & Sun, Z. J. (2020). Overexpression of ATAD2 indicates Poor Prognosis in Oral Squamous Cell Carcinoma. International journal of medical sciences, 17(11), 1598.

Wang, A. Q., Lv, M., Xu, Y. H., Xie, P. M., & Dong, Y. Y. (2020). MiR-200b-5p inhibits proliferation of ovarian cancer cells by targeting ATAD2 and regulating PI3K/AKT signaling pathway. Eur Rev Med Pharmacol Sci, 24(19), 9860-8.

Han, H. J., Huang, Q. Y., Huang, L. J., Chang, F., & Diao, Q. Z. (2019). Prognostic value of ATPase family, AAA+ domain containing 2 expression in human cancers: A systematic review and meta-analysis. Medicine, 98(39).

Liu, N., Funasaka, K., Obayashi, T., Miyahara, R., Hirooka, Y., Goto, H., & Senga, T. (2019). ATAD2 is associated with malignant characteristics of pancreatic cancer cells. Oncology letters, 17(3), 3489-3494.

Sun, T., Du, B., Diao, Y., Li, X., Chen, S., & Li, Y. (2019). ATAD2 expression increases [18F] Fluorodeoxyglucose uptake value in lung adenocarcinoma via AKT-GLUT1/HK2 pathway. BMB reports, 52(7), 457.

Hong, S., Chen, S., Wang, X., Sun, D., Yan, Z., Tai, J., & Bi, M. (2018). ATAD2 silencing decreases VEGFA secretion through targeting has-miR-520a to inhibit angiogenesis in colorectal cancer. Biochemistry and Cell Biology, 96(6), 761-768.

Sun, W., Lan, X., Zhang, H., Wang, Z., Dong, W., He, L., ... & Qin, Y. (2018). NEAT1_2 functions as a competing endogenous RNA to regulate ATAD2 expression by sponging microRNA-106b-5p in papillary thyroid cancer. Cell death & disease, 9(3), 1-15.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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