Rabbit Anti-ATAD2 Recombinant Antibody (CBYC-A832) (CBMAB-A3834-YC)

Name: Rabbit Anti-ATAD2 Recombinant Antibody (CBYC-A832)
SKU: CBMAB-A3834-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBYC-A832

Application

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ATAD2.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.05% BSA, 50% glycerol, pH7.3

Preservative

0.02% sodium azide

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ATAD2

Introduction

A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated wit

Entrez Gene ID

29028

UniProt ID

Q6PL18

Alternative Names

ATPase Family, AAA Domain Containing 2; AAA Nuclear Coregulator Cancer-Associated Protein; ANCCA; ATPase Family AAA Domain-Containing Protein 2; EC 3.6.1.3; PRO2000; CT137;

Function

May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.

Biological Process

Chromatin organization Source: InterPro
Negative regulation of chromatin silencing Source: GO_Central
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription by RNA polymerase II Source: Reactome

Cellular Location

Nucleus

Zhou, L., Yang, C., Zhang, N., Zhang, X., Zhao, T., & Yu, J. (2020). Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2. Biomedicine & Pharmacotherapy, 125, 109964.

Liu, Q., Liu, H., Li, L., Dong, X., Ru, X., Fan, X., ... & Liu, J. (2020). ATAD2 predicts poor outcomes in patients with ovarian cancer and is a marker of proliferation. International journal of oncology, 56(1), 219-231.

Potluri, L. B., Talluri, S., Buon, L., Samur, M. K., Aktas-Samur, A., Shi, J., ... & Munshi, N. C. (2020). Atpase Family AAA Domain-Containing Protein 2 (ATAD2) As a Novel Target in Multiple Myeloma. Blood, 136, 50.

Wang, X. L., Wang, S., Wu, Z. Z., Yang, Q. C., Li, H., Xiong, H. G., ... & Sun, Z. J. (2020). Overexpression of ATAD2 indicates Poor Prognosis in Oral Squamous Cell Carcinoma. International journal of medical sciences, 17(11), 1598.

Wang, A. Q., Lv, M., Xu, Y. H., Xie, P. M., & Dong, Y. Y. (2020). MiR-200b-5p inhibits proliferation of ovarian cancer cells by targeting ATAD2 and regulating PI3K/AKT signaling pathway. Eur Rev Med Pharmacol Sci, 24(19), 9860-8.

Han, H. J., Huang, Q. Y., Huang, L. J., Chang, F., & Diao, Q. Z. (2019). Prognostic value of ATPase family, AAA+ domain containing 2 expression in human cancers: A systematic review and meta-analysis. Medicine, 98(39).

Liu, N., Funasaka, K., Obayashi, T., Miyahara, R., Hirooka, Y., Goto, H., & Senga, T. (2019). ATAD2 is associated with malignant characteristics of pancreatic cancer cells. Oncology letters, 17(3), 3489-3494.

Sun, T., Du, B., Diao, Y., Li, X., Chen, S., & Li, Y. (2019). ATAD2 expression increases [18F] Fluorodeoxyglucose uptake value in lung adenocarcinoma via AKT-GLUT1/HK2 pathway. BMB reports, 52(7), 457.

Hong, S., Chen, S., Wang, X., Sun, D., Yan, Z., Tai, J., & Bi, M. (2018). ATAD2 silencing decreases VEGFA secretion through targeting has-miR-520a to inhibit angiogenesis in colorectal cancer. Biochemistry and Cell Biology, 96(6), 761-768.

Sun, W., Lan, X., Zhang, H., Wang, Z., Dong, W., He, L., ... & Qin, Y. (2018). NEAT1_2 functions as a competing endogenous RNA to regulate ATAD2 expression by sponging microRNA-106b-5p in papillary thyroid cancer. Cell death & disease, 9(3), 1-15.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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