Sign in or Register   Sign in or Register
  |  

Rabbit Anti-ATAD2 Recombinant Antibody (CBYC-A832) (CBMAB-A3834-YC)

Provided herein is a Mouse monoclonal antibody against Human ATPase Family, AAA Domain Containing 2. The antibody can be used for immunoassay techniques, such as IP.
See all ATAD2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYC-A832
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ATAD2.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.05% BSA, 50% glycerol, pH7.3
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATAD2
Introduction
A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated wit
Entrez Gene ID
29028
UniProt ID
Q6PL18
Alternative Names
ATPase Family, AAA Domain Containing 2; AAA Nuclear Coregulator Cancer-Associated Protein; ANCCA; ATPase Family AAA Domain-Containing Protein 2; EC 3.6.1.3; PRO2000; CT137;
Function
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.
Biological Process
Chromatin organization Source: InterPro
Negative regulation of chromatin silencing Source: GO_Central
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription by RNA polymerase II Source: Reactome
Cellular Location
Nucleus

Zhou, L., Yang, C., Zhang, N., Zhang, X., Zhao, T., & Yu, J. (2020). Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2. Biomedicine & Pharmacotherapy, 125, 109964.

Liu, Q., Liu, H., Li, L., Dong, X., Ru, X., Fan, X., ... & Liu, J. (2020). ATAD2 predicts poor outcomes in patients with ovarian cancer and is a marker of proliferation. International journal of oncology, 56(1), 219-231.

Potluri, L. B., Talluri, S., Buon, L., Samur, M. K., Aktas-Samur, A., Shi, J., ... & Munshi, N. C. (2020). Atpase Family AAA Domain-Containing Protein 2 (ATAD2) As a Novel Target in Multiple Myeloma. Blood, 136, 50.

Wang, X. L., Wang, S., Wu, Z. Z., Yang, Q. C., Li, H., Xiong, H. G., ... & Sun, Z. J. (2020). Overexpression of ATAD2 indicates Poor Prognosis in Oral Squamous Cell Carcinoma. International journal of medical sciences, 17(11), 1598.

Wang, A. Q., Lv, M., Xu, Y. H., Xie, P. M., & Dong, Y. Y. (2020). MiR-200b-5p inhibits proliferation of ovarian cancer cells by targeting ATAD2 and regulating PI3K/AKT signaling pathway. Eur Rev Med Pharmacol Sci, 24(19), 9860-8.

Han, H. J., Huang, Q. Y., Huang, L. J., Chang, F., & Diao, Q. Z. (2019). Prognostic value of ATPase family, AAA+ domain containing 2 expression in human cancers: A systematic review and meta-analysis. Medicine, 98(39).

Liu, N., Funasaka, K., Obayashi, T., Miyahara, R., Hirooka, Y., Goto, H., & Senga, T. (2019). ATAD2 is associated with malignant characteristics of pancreatic cancer cells. Oncology letters, 17(3), 3489-3494.

Sun, T., Du, B., Diao, Y., Li, X., Chen, S., & Li, Y. (2019). ATAD2 expression increases [18F] Fluorodeoxyglucose uptake value in lung adenocarcinoma via AKT-GLUT1/HK2 pathway. BMB reports, 52(7), 457.

Hong, S., Chen, S., Wang, X., Sun, D., Yan, Z., Tai, J., & Bi, M. (2018). ATAD2 silencing decreases VEGFA secretion through targeting has-miR-520a to inhibit angiogenesis in colorectal cancer. Biochemistry and Cell Biology, 96(6), 761-768.

Sun, W., Lan, X., Zhang, H., Wang, Z., Dong, W., He, L., ... & Qin, Y. (2018). NEAT1_2 functions as a competing endogenous RNA to regulate ATAD2 expression by sponging microRNA-106b-5p in papillary thyroid cancer. Cell death & disease, 9(3), 1-15.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-ATAD2 Recombinant Antibody (CBYC-A832)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare