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Mouse Anti-ATF3 Recombinant Antibody (CBCNC-120) (CBMAB-C1084-CN)

This product is a Mouse antibody that recognizes ATF3. The antibody CBCNC-120 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-F, ELISA.
See all ATF3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNC-120
Antibody Isotype
IgG1
Application
WB, FC, ELISA

Basic Information

Immunogen
Purified recombinant fragment of human ATF3 (AA: 1-181) expressed in E. coli.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000
FC1:200-1:400

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.05% sodium azide
Concentration
1 mg/ml

Target

Full Name
activating transcription factor 3
Introduction
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
Entrez Gene ID
467
UniProt ID
P18847
Alternative Names
Activating Transcription Factor 3; CAMP-Dependent Transcription Factor ATF-3;
Function
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter.
Isoform 2: Activates transcription presumably by sequestering inhibitory cofactors away from the promoters.
Biological Process
Cellular response to amino acid starvation Source: Ensembl
Endoplasmic reticulum unfolded protein response Source: Ensembl
Gluconeogenesis Source: Ensembl
Negative regulation of ERK1 and ERK2 cascade Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: ParkinsonsUK-UCL
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Positive regulation of TRAIL-activated apoptotic signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
Regulation of eIF2 alpha phosphorylation by heme Source: Reactome
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance Source: ParkinsonsUK-UCL
Skeletal muscle cell differentiation Source: Ensembl
Cellular Location
Nucleus

Ku, H. C., & Cheng, C. F. (2020). Master regulator activating transcription factor 3 (ATF3) in metabolic homeostasis and cancer. Frontiers in Endocrinology, 11.

Kole, C., Brommer, B., Nakaya, N., Sengupta, M., Bonet-Ponce, L., Zhao, T., ... & Tomarev, S. (2020). Activating transcription factor 3 (ATF3) protects retinal ganglion cells and promotes functional preservation after optic nerve crush. Investigative ophthalmology & visual science, 61(2), 31-31.

Li, X., Zang, S., Cheng, H., Li, J., & Huang, A. (2019). Overexpression of activating transcription factor 3 exerts suppressive effects in HepG2 cells. Molecular medicine reports, 19(2), 869-876.

Wu, C., Lin, H., & Zhang, X. (2019). Inhibitory effects of pirfenidone on fibroblast to myofibroblast transition in rheumatoid arthritis-associated interstitial lung disease via the downregulation of activating transcription factor 3 (ATF3). International immunopharmacology, 74, 105700.

Förstner, P., Rehman, R., Anastasiadou, S., Haffner-Luntzer, M., Sinske, D., Ignatius, A., ... & Knöll, B. (2018). Neuroinflammation after traumatic brain injury is enhanced in activating transcription factor 3 mutant mice. Journal of neurotrauma, 35(19), 2317-2329.

Rohini, M., Menon, A. H., & Selvamurugan, N. (2018). Role of activating transcription factor 3 and its interacting proteins under physiological and pathological conditions. International journal of biological macromolecules, 120, 310-317.

Zhou, H., Li, N., Yuan, Y., Jin, Y. G., Guo, H., Deng, W., & Tang, Q. Z. (2018). Activating transcription factor 3 in cardiovascular diseases: a potential therapeutic target. Basic research in cardiology, 113(5), 1-13.

Hasim, M. S., Nessim, C., Villeneuve, P. J., Vanderhyden, B. C., & Dimitroulakos, J. (2018). Activating transcription factor 3 as a novel regulator of chemotherapy response in breast cancer. Translational oncology, 11(4), 988-998.

Li, Y., Li, Z., Zhang, C., Li, P., Wu, Y., Wang, C., ... & Du, J. (2017). Cardiac Fibroblast–specific activating transcription factor 3 protects against heart failure by suppressing MAP2K3-p38 signaling. Circulation, 135(21), 2041-2057.

Li, X., Zhou, X., Li, Y., Zu, L., Pan, H., Liu, B., ... & Zhou, Q. (2017). Activating transcription factor 3 promotes malignance of lung cancer cells in vitro. Thoracic cancer, 8(3), 181-191.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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