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Rabbit Anti-ATG4C Recombinant Antibody (EG294) (CBMAB-EN323-LY)

The product is antibody recognizes ATG4C . The antibody EG294 immunoassay techniques such as: WB: 1:500~1:1000 IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:20000.
See all ATG4C antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG294
Antibody Isotype
IgG
Application
WB, IHC, IF, ELISA

Basic Information

Immunogen
Recombinant protein of human ATG4C.
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)20 µg/ml
IHC-P1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50nM Tris-Glycine, pH 7.4, 0.15M NaCl, 40% Glycerol, 0.05% BSA
Preservative
0.01% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Autophagy Related 4C Cysteine Peptidase
Introduction
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human84938
Mouse242557
UniProt ID
HumanQ96DT6
MouseQ811C2
Alternative Names
Autophagy Related 4C Cysteine Peptidase; Autophagy-Related Cysteine Endopeptidase 3; Autophagy-Related Protein 4 Homolog C; AUT-Like 3 Cysteine Endopeptidase; Autophagin-3; AUTL1; APG4C; AUTL3; AUT (S. Cerevisiae)-Like 1, Cysteine Endopeptidase; AUT-Like 1, Cysteine Endopeptidase (S. Cerevisiae); ATG4 Autophagy Related 4 Homolog C (S. Cerevisiae);
Function
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Biological Process
Autophagy Source: UniProtKB-KW
Protein transport Source: UniProtKB-KW
Proteolysis Source: UniProtKB
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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