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Rabbit Anti-ATP1A3 Recombinant Antibody (SR1002) (CBMAB-1163-CN)

This product is a rabbit antibody that recognizes ATP1A3 of human. The antibody EPR14137 can be used for immunoassay techniques such as: WB.
See all ATP1A3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
SR1002
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
A synthesized peptide derived from human Sodium Potassium ATPase Alpha 3.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 150mM NaCl, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATPase Na+/K+ Transporting Subunit Alpha 3
Introduction
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Entrez Gene ID
Human478
Mouse232975
Rat24213
UniProt ID
HumanP13637
MouseQ6PIC6
RatP06687
Alternative Names
RDP; AHC2; CAPOS; DYT12; ATP1A1
Function
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Biological Process
Cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
Cellular potassium ion homeostasis Source: BHF-UCL
Cellular response to amyloid-beta Source: ARUK-UCL
Cellular response to steroid hormone stimulus Source: BHF-UCL
Cellular sodium ion homeostasis Source: BHF-UCL
Ion transmembrane transport Source: Reactome
Neuron projection maintenance Source: ARUK-UCL
Potassium ion import across plasma membrane Source: BHF-UCL
Proton transmembrane transport Source: GO_Central
Regulation of cardiac conduction Source: Reactome
Regulation of resting membrane potential Source: ARUK-UCL
Response to glycoside Source: BHF-UCL
Sodium ion export across plasma membrane Source: BHF-UCL
Cellular Location
Cell membrane
Involvement in disease
Dystonia 12 (DYT12): An autosomal dominant dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT12 patients develop dystonia and parkinsonism between 15 and 45 years of age. The disease is characterized by an unusually rapid evolution of signs and symptoms. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability.
Alternating hemiplegia of childhood 2 (AHC2): A rare syndrome of episodic hemi- or quadriplegia lasting minutes to days. Most cases are accompanied by dystonic posturing, choreoathetoid movements, nystagmus, other ocular motor abnormalities, autonomic disturbances, and progressive cognitive impairment. It is typically distinguished from familial hemiplegic migraine by infantile onset and high prevalence of associated neurological deficits that become increasingly obvious with age.
Cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss (CAPOS): An autosomal dominant neurologic disorder characterized by relapsing and partially remitting, early-onset cerebellar ataxia following a febrile illness. Other features include progressive optic atrophy and sensorineural hearing loss, generalized hypotonia, areflexia and pes cavus without evidence of a peripheral neuropathy on neurophysiological studies.
Topology
Cytoplasmic: 1-77 aa
Helical: 78-98 aa
Extracellular: 99-121 aa
Helical: 122-142 aa
Cytoplasmic: 143-278 aa
Helical: 279-298 aa
Extracellular: 299-310 aa
Helical: 311-328 aa
Cytoplasmic: 329-762 aa
Helical: 763-782 aa
Extracellular: 783-792 aa
Helical: 793-813 aa
Cytoplasmic: 814-833 aa
Helical: 834-856 aa
Extracellular: 857-908 aa
Helical: 909-928 aa
Cytoplasmic: 929-941 aa
Helical: 942-960 aa
Extracellular: 961-975 aa
Helical: 976-996 aa
Cytoplasmic: 997-1013 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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