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Mouse Anti-ATP1B3 Recombinant Antibody (2F4) (CBMAB-A4022-YC)

Provided herein is a Mouse monoclonal antibody against Human ATPase Na+/K+ Transporting Subunit Beta 3. The antibody can be used for immunoassay techniques, such as FC.
See all ATP1B3 antibodies
Published Data
Mouse Anti-ATP1B3 Recombinant Antibody (2F4) (CBMAB-A4022-YC) in IF
Immunofluorescent localization of ATP1B3 in bovine blastocysts fixed with 4% paraformaldehyde. Three different primary antibodies were used in combination with a goat-anti-mouse FITC-labelled secondary antibody. The nuclei were stained with propidium iodide (40·magnification). ...View More
Goossens, K., Vandaele, L., Wydooghe, E., Thys, M., Dewulf, J., Peelman, L. J., & Van Soom, A. (2011). The importance of adequate fixation for immunofluorescent staining of bovine embryos. Reproduction in Domestic Animals, 46(6), 1098-1103.

Summary

Host Animal
Mouse
Specificity
Human
Clone
2F4
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
ATP1B3 (AAH11835, 1 a.a. ~ 279 a.a) full-length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATPase Na+/K+ Transporting Subunit Beta 3
Introduction
ATP1B3 belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K io
Entrez Gene ID
483
UniProt ID
P54709
Alternative Names
ATPase Na+/K+ Transporting Subunit Beta 3; Sodium-Potassium ATPase Subunit Beta 3 (Non-Catalytic); Sodium/Potassium-Transporting ATPase Subunit Beta-3; Sodium/Potassium-Dependent ATPase Subunit Beta-3; ATPase, Na+/K+ Transporting, Beta 3 Polypeptide; Sodi
Function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.
Biological Process
Cellular potassium ion homeostasis Source: BHF-UCL
Cellular sodium ion homeostasis Source: BHF-UCL
Ion transmembrane transport Source: Reactome
Leukocyte migration Source: Reactome
Membrane repolarization Source: BHF-UCL
Positive regulation of ATPase activity Source: BHF-UCL
Positive regulation of potassium ion import across plasma membrane Source: BHF-UCL
Positive regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
Positive regulation of sodium ion export across plasma membrane Source: BHF-UCL
Potassium ion import across plasma membrane Source: BHF-UCL
Potassium ion transmembrane transport Source: ARUK-UCL
Protein localization to plasma membrane Source: BHF-UCL
Protein stabilization Source: BHF-UCL
Regulation of cardiac conduction Source: Reactome
Sodium ion export across plasma membrane Source: BHF-UCL
Sodium ion transmembrane transport Source: ARUK-UCL
Cellular Location
Apical cell membrane; Basolateral cell membrane; Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Topology
Cytoplasmic: 1-35 aa
Helical: 36-56 aa
Extracellular: 57-279 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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