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ATP1B3

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]

Full Name

ATPase Na+/K+ Transporting Subunit Beta 3

Function

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

Biological Process

Cellular potassium ion homeostasis Source: BHF-UCL
Cellular sodium ion homeostasis Source: BHF-UCL
Ion transmembrane transport Source: Reactome
Leukocyte migration Source: Reactome
Membrane repolarization Source: BHF-UCL
Positive regulation of ATPase activity Source: BHF-UCL
Positive regulation of potassium ion import across plasma membrane Source: BHF-UCL
Positive regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
Positive regulation of sodium ion export across plasma membrane Source: BHF-UCL
Potassium ion import across plasma membrane Source: BHF-UCL
Potassium ion transmembrane transport Source: ARUK-UCL
Protein localization to plasma membrane Source: BHF-UCL
Protein stabilization Source: BHF-UCL
Regulation of cardiac conduction Source: Reactome
Sodium ion export across plasma membrane Source: BHF-UCL
Sodium ion transmembrane transport Source: ARUK-UCL

Cellular Location

Apical cell membrane; Basolateral cell membrane; Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Topology

Cytoplasmic: 1-35 aa
Helical: 36-56 aa
Extracellular: 57-279 aa

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Anti-ATP1B3 antibodies

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Mouse Anti-ATP1B3 Recombinant Antibody (1E9) (CBMAB-A4021-YC)

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Target: ATP1B3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1E9

Application*: E

Rabbit Anti-ATP1B3 Recombinant Antibody (EG300) (CBMAB-EN330-LY)

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Target: ATP1B3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG300

Application*: WB, IH

Mouse Anti-ATP1B3 Recombinant Antibody (2F5) (CBMAB-A0615-LY)

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Target: ATP1B3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2F5

Application*: E

Mouse Anti-ATP1B3 Recombinant Antibody (CBXC-2896) (CBMAB-C5150-CQ)

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Target: ATP1B3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXC-2896

Application*: IF, IP, WB

Human Anti-ATP1B3 Recombinant Antibody (CBXC-0751) (CBMAB-C1865-CQ)

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Target: ATP1B3

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0751

Application*: FC, IF, IH

Mouse Anti-ATP1B3 Recombinant Antibody (2F4) (CBMAB-A4022-YC)

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Target: ATP1B3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2F4

Application*: E

Mouse Anti-ATP1B3 Recombinant Antibody (CBWJN-0401) (CBMAB-N0630-WJ)

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Target: ATP1B3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJN-0401

Application*: IF, IP, WB

Mouse Anti-ATP1B3 Recombinant Antibody (CBT3487) (V2LY-0625-LY1610)

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Target: ATP1B3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT3487

Application*: IH, F

Mouse Anti-ATP1B3 Recombinant Antibody (CBT2550) (V2LY-0625-LY1609)

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Target: ATP1B3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT2550

Application*: F

ATP1B3 Matched Antibody Pair (116) (APMAB-116LY)

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Target: ATP1B3

Specificity: Human

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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