ATP1B3

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]
Full Name
ATPase Na+/K+ Transporting Subunit Beta 3
Function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.
Biological Process
Cellular potassium ion homeostasis Source: BHF-UCL
Cellular sodium ion homeostasis Source: BHF-UCL
Ion transmembrane transport Source: Reactome
Leukocyte migration Source: Reactome
Membrane repolarization Source: BHF-UCL
Positive regulation of ATPase activity Source: BHF-UCL
Positive regulation of potassium ion import across plasma membrane Source: BHF-UCL
Positive regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
Positive regulation of sodium ion export across plasma membrane Source: BHF-UCL
Potassium ion import across plasma membrane Source: BHF-UCL
Potassium ion transmembrane transport Source: ARUK-UCL
Protein localization to plasma membrane Source: BHF-UCL
Protein stabilization Source: BHF-UCL
Regulation of cardiac conduction Source: Reactome
Sodium ion export across plasma membrane Source: BHF-UCL
Sodium ion transmembrane transport Source: ARUK-UCL
Cellular Location
Apical cell membrane; Basolateral cell membrane; Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Topology
Cytoplasmic: 1-35 aa
Helical: 36-56 aa
Extracellular: 57-279 aa
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Anti-ATP1B3 antibodies

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Mouse Anti-ATP1B3 Recombinant Antibody (1E9) (CBMAB-A4021-YC)

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Target: ATP1B3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E9
Application*: E
Datasheet SDS

Rabbit Anti-ATP1B3 Recombinant Antibody (EG300) (CBMAB-EN330-LY)

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Target: ATP1B3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG300
Application*: WB, IH
Datasheet SDS

Mouse Anti-ATP1B3 Recombinant Antibody (2F5) (CBMAB-A0615-LY)

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Target: ATP1B3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2F5
Application*: E
Datasheet SDS

Mouse Anti-ATP1B3 Recombinant Antibody (CBXC-2896) (CBMAB-C5150-CQ)

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Target: ATP1B3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-2896
Application*: IF, IP, WB
Datasheet SDS

Human Anti-ATP1B3 Recombinant Antibody (CBXC-0751) (CBMAB-C1865-CQ)

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Target: ATP1B3
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0751
Application*: FC, IF, IH
Datasheet SDS

Mouse Anti-ATP1B3 Recombinant Antibody (2F4) (CBMAB-A4022-YC)

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Target: ATP1B3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2F4
Application*: E
Datasheet SDS

Mouse Anti-ATP1B3 Recombinant Antibody (CBWJN-0401) (CBMAB-N0630-WJ)

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Target: ATP1B3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0401
Application*: IF, IP, WB
Datasheet SDS

Mouse Anti-ATP1B3 Recombinant Antibody (CBT3487) (V2LY-0625-LY1610)

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Target: ATP1B3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3487
Application*: IH, F
Datasheet SDS

Mouse Anti-ATP1B3 Recombinant Antibody (CBT2550) (V2LY-0625-LY1609)

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Target: ATP1B3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2550
Application*: F
Datasheet SDS

ATP1B3 Matched Antibody Pair (116) (APMAB-116LY)

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Target: ATP1B3
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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