Mouse Anti-ATP6V0D1 Recombinant Antibody (3B8) (CBMAB-A4079-YC)

Name: Mouse Anti-ATP6V0D1 Recombinant Antibody (3B8)
SKU: CBMAB-A4079-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

3B8

Application

ELISA, WB

Immunogen

ATP6V0D1 (NP_004682, 238-308 aa) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 238-308

More Infomation

Target

Full Name

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1

Introduction

ATP6V0D1 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, z

Entrez Gene ID

9114

UniProt ID

P61421

Alternative Names

ATPase H+ Transporting V0 Subunit D1; ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump), Member D; ATPase, H+ Transporting, Lysosomal 38kDa, V0 Subunit D1; V-ATPase 40 KDa Accessory Protein; Vacuolar Proton Pump Subunit D 1; 32 KDa Accessory Prote

Function

Subunit of the integral membrane V0 complex of the lysosomal proton-transporting V-type ATPase (v-ATPase) (PubMed:28296633, PubMed:30374053).
V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (PubMed:30374053).
May play a role in coupling of proton transport and ATP hydrolysis (By similarity).
In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).
May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity).

Biological Process

Cellular iron ion homeostasis Source: UniProtKB
Cellular response to amino acid starvation Source: Reactome
Cellular response to increased oxygen levels Source: UniProtKB
Cilium assembly Source: UniProtKB
Insulin receptor signaling pathway Source: Reactome
Ion transmembrane transport Source: Reactome
IRE1-mediated unfolded protein response Source: Reactome
Phagosome acidification Source: Reactome
Proton transmembrane transport Source: UniProtKB
Regulation of macroautophagy Source: ParkinsonsUK-UCL
Transferrin transport Source: Reactome
Vacuolar acidification Source: GO_Central
Vacuolar transport Source: GO_Central

Cellular Location

Lysosome membrane; Membrane. Localizes to centrosome and the base of the cilium.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-ATP6V0D1 Recombinant Antibody (3B7) (CAT#: CBMAB-A4078-YC)

Mouse Anti-ATP6V0D1 Recombinant Antibody (2G12) (CAT#: CBMAB-A4077-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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