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Mouse Anti-AUP1 Recombinant Antibody (CBT4577) (V2LY-0625-LY1054)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBT4577
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Purified recombinant fragment of human AUP1 (AA: 229-410) expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
AUP1, Lipid Droplet Regulating VLDL Assembly Factor
Entrez Gene ID
550
UniProt ID
Q9Y679
Function
Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (PubMed:18711132, PubMed:21857022).
Plays a role in lipid droplet formation (PubMed:21857022).
Induces lipid droplet clustering (PubMed:24039768).
Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation (PubMed:23223569, PubMed:21127063).
Also required for the degradation of INSIG1, SREBF1 and SREBF2 (PubMed:23223569).
Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB (PubMed:28183703).
(Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles.
Biological Process
ER-associated misfolded protein catabolic process Source: UniProtKB
Lipid droplet formation Source: UniProtKB
Lipid droplet organization Source: UniProtKB
Lipophagy Source: UniProtKB
Protein localization to lipid droplet Source: UniProtKB
Response to virus Source: UniProtKB
Retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCL
Ubiquitin-dependent ERAD pathway Source: UniProtKB
Viral process Source: UniProtKB-KW
Cellular Location
Endoplasmic reticulum membrane; Lipid droplet; Autophagosome. (Microbial infection) Upon Dengue virus infection, relocates from lipid droplets to autophagosomes.
Topology
Cytoplasmic: 1-20 aa
Intramembrane: 21-41 aa
Cytoplasmic: 42-410 aa
PTM
Monoubiquitinated and diubiquitinated.
(Microbial infection) Not ubiquitinated following Dengue virus infection.
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For research use only. Not intended for any clinical use.

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