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Mouse Anti-AZIN1 Recombinant Antibody (1F11) (CBMAB-A0676-LY)

The product is antibody recognizes AZIN1. The antibody 1F11 immunoassay techniques such as: WB, ELISA.
See all AZIN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F11
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
AZIN1 (NP_056962, 339 a.a. ~ 447 a.a) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
antizyme inhibitor 1
Introduction
Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
Entrez Gene ID
51582
UniProt ID
O14977
Alternative Names
MGC3832; MGC691; OAZI; OAZIN; ODC1L
Function
Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948).
Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240).
Biological Process
Negative regulation of protein catabolic process Source: UniProtKB
Positive regulation of polyamine transmembrane transport Source: UniProtKB
Putrescine biosynthetic process from ornithine Source: GO_Central
Regulation of cellular amino acid metabolic process Source: Reactome
Cellular Location
Nucleus
PTM
Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizyme OAZ1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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