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Mouse Anti-AZIN1 Recombinant Antibody (1G8) (CBMAB-A4245-YC)

Provided herein is a Mouse monoclonal antibody against Human Antizyme Inhibitor 1. The antibody can be used for immunoassay techniques, such as WB, ICC, IF.
See all AZIN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
1G8
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 260-448 of human AZIN1 produced in E.coli.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
antizyme inhibitor 1
Introduction
AZIN1 belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynt
Entrez Gene ID
51582
UniProt ID
O14977
Alternative Names
Antizyme Inhibitor 1; Ornithine Decarboxylase Antizyme Inhibitor; OAZIN; AZI1; OAZI; AZI;
Function
Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948).
Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240).
Biological Process
Negative regulation of protein catabolic process Source: UniProtKB
Positive regulation of polyamine transmembrane transport Source: UniProtKB
Putrescine biosynthetic process from ornithine Source: GO_Central
Regulation of cellular amino acid metabolic process Source: Reactome
Cellular Location
Nucleus
PTM
Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizyme OAZ1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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