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Mouse Anti-B3GAT1 Recombinant Antibody (CBT2117) (V2LY-0625-LY549)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2117
Antibody Isotype
IgG1
Application
WB, FC

Basic Information

Immunogen
Purified recombinant fragment of human B3GAT1 (AA: 193-334) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Beta-1,3-Glucuronyltransferase 1
Entrez Gene ID
27087
UniProt ID
Q9P2W7
Function
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.
Biological Process
Carbohydrate metabolic process Source: GO_Central
Cellular response to hypoxia Source: Ensembl
Chondroitin sulfate proteoglycan biosynthetic process Source: GO_Central
Glycosaminoglycan metabolic process Source: Reactome
Protein glycosylation Source: UniProtKB-UniPathway
Cellular Location
Isoform 1: Secreted; Golgi apparatus membrane
Isoform 2: Secreted; Golgi apparatus membrane; Endoplasmic reticulum membrane
Topology
Cytoplasmic: 1-6 aa
Helical: 7-27 aa
Lumenal: 28-334 aa
PTM
The soluble form derives from the membrane form by proteolytic processing.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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