B3GAT1

The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Full Name
Beta-1,3-Glucuronyltransferase 1
Function
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.
Biological Process
Carbohydrate metabolic process Source: GO_Central
Cellular response to hypoxia Source: Ensembl
Chondroitin sulfate proteoglycan biosynthetic process Source: GO_Central
Glycosaminoglycan metabolic process Source: Reactome
Protein glycosylation Source: UniProtKB-UniPathway
Cellular Location
Isoform 1: Secreted; Golgi apparatus membrane
Isoform 2: Secreted; Golgi apparatus membrane; Endoplasmic reticulum membrane
Topology
Cytoplasmic: 1-6 aa
Helical: 7-27 aa
Lumenal: 28-334 aa
PTM
The soluble form derives from the membrane form by proteolytic processing.
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Anti-B3GAT1 antibodies

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Mouse Anti-B3GAT1 Recombinant Antibody (IHC539) (CBMAB-MA017-YC)

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Target: B3GAT1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: IHC539
Application*: IH
Datasheet SDS

Mouse Anti-B3GAT1 Recombinant Antibody (TBO1) (CBMAB-C9486-LY)

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Target: B3GAT1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: TBO1
Application*: FC, IF, IC, IH
Datasheet SDS

Mouse Anti-B3GAT1 Recombinant Antibody (6-13-19-1) (CBMAB-C7871-LY)

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Target: B3GAT1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 6-13-19-1
Application*: IH, IF
Datasheet SDS

Mouse Anti-B3GAT1 Recombinant Antibody (HNK-1) (CBMAB-G0007-LY)

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Target: B3GAT1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: HNK-1
Application*: FC, IF, P, WB, IP
Datasheet SDS

Mouse Anti-B3GAT1 Recombinant Antibody (CBT2117) (V2LY-0625-LY549)

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Target: B3GAT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2117
Application*: WB, F
Datasheet SDS

Mouse Anti-B3GAT1 Recombinant Antibody (CBT4437) (V2LY-0625-LY548)

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Target: B3GAT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4437
Application*: F
Datasheet SDS

Mouse Anti-B3GAT1 Recombinant Antibody (CBT3622) (V2LY-0625-LY1568)

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Target: B3GAT1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3622
Application*: IH, F
Datasheet SDS

Mouse Anti-B3GAT1 Recombinant Antibody (CBT2100) (V2LY-0625-LY1471)

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Target: B3GAT1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT2100
Application*: IH, F
Datasheet SDS

Mouse Anti-B3GAT1 Recombinant Antibody (CBT4608) (V2LY-0625-LY1047)

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Target: B3GAT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: CBT4608
Application*: WB, F
Datasheet SDS

Mouse Anti-B3GAT1 Recombinant Antibody (SPM129) (CBMAB-C5849-CQ)

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Target: B3GAT1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: SPM129
Application*: IH, IF
Datasheet SDS

Mouse Anti-B3GAT1 Recombinant Antibody (NK-1) (CBMAB-C5848-CQ)

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Target: B3GAT1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat
Clone: NK-1
Application*: FC, IF, P, WB, IP
Datasheet SDS

Mouse Anti-B3GAT1 Recombinant Antibody (CDLA57) (CBMAB-H0843-FY)

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Target: B3GAT1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CDLA57
Application*: IH
Datasheet SDS

Mouse Anti-B3GAT1 Recombinant Antibody (CBYY-2130) (CBMAB-2479-YY)

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Target: B3GAT1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-2130
Application*: IH
Datasheet SDS

Mouse Anti-B3GAT1 Recombinant Antibody (CBYY-2070) (CBMAB-2419-YY)

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Target: B3GAT1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-2070
Application*: IF, IC
Datasheet SDS

Mouse Anti-B3GAT1 Recombinant Antibody (CBYY-0072) (CBMAB-0072-YY)

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Target: B3GAT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-0072
Application*: IH, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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