Mouse Anti-BANP Recombinant Antibody (CBYY-1874) (CBMAB-2223-YY)

Name: Mouse Anti-BANP Recombinant Antibody (CBYY-1874)
SKU: CBMAB-2223-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-1874

Application

WB, IP

Immunogen

Amino acids 30-390 of BANP of human origin.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

BTG3 associated nuclear protein

Introduction

This gene encodes a protein that binds to matrix attachment regions. The protein forMouse a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforMouse have been found for this gene. [provided by RefSeq, Mar 2010]

Entrez Gene ID

54971

UniProt ID

Q8N9N5

Alternative Names

BTG3 Associated Nuclear Protein; Scaffold/Matrix-Associated Region-1-Binding Protein; BEN Domain-Containing Protein 1; BEND1; SMAR1; Btg3-Associated Nuclear Protein; BEN Domain Containing 1; Protein BANP; SMARBP1;

Function

Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest (By similarity).

Biological Process

Cell cycle Source: UniProtKB-KW
Chromatin organization Source: UniProtKB-KW
Multicellular organism development Source: UniProtKB-KW
Negative regulation of protein catabolic process Source: GO_Central
Positive regulation of transcription, DNA-templated Source: Ensembl
Protein localization to nucleus Source: GO_Central
Regulation of signal transduction by p53 class mediator Source: Reactome

Cellular Location

Nucleus

Chen, G., Li, Y., Zhang, A., & Gao, L. (2021). Circular RNA Circ-BANP Regulates Oxidized Low-density Lipoprotein-induced Endothelial Cell Injury Through Targeting the miR-370/Thioredoxin-interacting Protein Axis. Journal of Cardiovascular Pharmacology, 77(3), 349-359.

Grand, R. S., Burger, L., Gräwe, C., Michael, A. K., Isbel, L., Hess, D., ... & Schübeler, D. (2021). BANP opens chromatin and activates CpG-island-regulated genes. Nature, 596(7870), 133-137.

Zhang, Y., Shen, K., Zha, H., Zhang, W., & Zhang, H. (2021). Circ-BANP Contributes to Cell Carcinogenesis and Aerobic Glycolysis by Regulating MAPK1 Through miR-874-3p in Colorectal Cancer.

Chen, G., Li, Y., Zhang, A., & Gao, L. (2020). Circular RNA circ-BANP regulates ox-LDL-induced endothelial cell injury through targeting the miR-370/TXNIP axis. Journal of Cardiovascular Pharmacology.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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