BANP

This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene.

Full Name

BTG3 associated nuclear protein

Function

Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest (By similarity).

Biological Process

Cell cycle Source: UniProtKB-KW
Chromatin organization Source: UniProtKB-KW
Multicellular organism development Source: UniProtKB-KW
Negative regulation of protein catabolic process Source: GO_Central
Positive regulation of transcription, DNA-templated Source: Ensembl
Protein localization to nucleus Source: GO_Central
Regulation of signal transduction by p53 class mediator Source: Reactome

Cellular Location

Nucleus