Mouse Anti-BAZ1A Recombinant Antibody (1F6) (CBMAB-A0719-LY)

Name: Mouse Anti-BAZ1A Recombinant Antibody (1F6)
SKU: CBMAB-A0719-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1F6

Application

WB, ELISA

Immunogen

BAZ1A (NP_038476, 1457 a.a. ~ 1556 a.a) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

bromodomain adjacent to zinc finger domain, 1A

Entrez Gene ID

11177

UniProt ID

Q9NRL2

Alternative Names

ACF1; DKFZp586E0518; FLJ14383; WALp1; WCRF180; hACF1

Function

Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression.
Component of the histone-fold protein complex CHRAC complex which facilitates nucleosome sliding by the ACF complex and enhances ACF-mediated chromatin assembly. The C-terminal regions of both CHRAC1 and POLE1 are required for these functions.

Biological Process

Chromatin remodeling Source: BHF-UCL
DNA-dependent DNA replication Source: UniProtKB
Histone acetylation Source: GOC
Regulation of transcription by RNA polymerase II Source: BHF-UCL

Cellular Location

Nucleus. May target the CHRAC complex to heterochromatin.

Yang, Z., Zhou, Y., & Zhong, L. (2021). Discovery of BAZ1A bromodomain inhibitors with the aid of virtual screening and activity evaluation. Bioorganic & Medicinal Chemistry Letters, 33, 127745.

Li, X., Ding, D., Yao, J., Zhou, B., Shen, T., Qi, Y., ... & Wei, G. (2019). Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells. Life sciences, 229, 225-232.

Oppikofer, M., Sagolla, M., Haley, B., Zhang, H. M., Kummerfeld, S. K., Sudhamsu, J., ... & Cochran, A. G. (2017). Non-canonical reader modules of BAZ1A promote recovery from DNA damage. Nature communications, 8(1), 1-15.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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