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Mouse Anti-BAZ1A Recombinant Antibody (CBYY-0231) (CBMAB-0232-YY)

This product is mouse antibody that recognizes BAZ1A. The antibody CBYY-0231 can be used for immunoassay techniques such as: WB, IP, IF, ELISA
See all BAZ1A antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-0231
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 8-33 at the N-terminus of BAZ1A of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
bromodomain adjacent to zinc finger domain, 1A
Introduction
The BAZ1A gene encodes the accessory subunit of the ATP-dependent chromatin assembly factor (ACF), a member of the ISWI ('imitation switch') family of chromatin remodeling complexes (summarized by Racki et al., 2009 [PubMed 20033039]).[supplied by OMIM, Apr 2010]
Entrez Gene ID
11177
UniProt ID
Q9NRL2
Alternative Names
Bromodomain Adjacent To Zinc Finger Domain 1A; WilliaMouse Syndrome Transcription Factor-Related Chromatin-Remodeling Factor 180; ATP-Utilizing Chromatin Assembly And Remodeling Factor 1; CHRAC Subunit ACF1; WCRF180; HWALp1; HACF1;
Function
Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression.
Component of the histone-fold protein complex CHRAC complex which facilitates nucleosome sliding by the ACF complex and enhances ACF-mediated chromatin assembly. The C-terminal regions of both CHRAC1 and POLE1 are required for these functions.
Biological Process
Chromatin remodeling Source: BHF-UCL
DNA-dependent DNA replication Source: UniProtKB
Histone acetylation Source: GOC
Regulation of transcription by RNA polymerase II Source: BHF-UCL
Cellular Location
Nucleus. May target the CHRAC complex to heterochromatin.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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