Mouse Anti-BBOX1 Recombinant Antibody (6H3) (CBMAB-A0723-LY)

The product is antibody recognizes BBOX1. The antibody 6H3 immunoassay techniques such as: WB, ELISA.
See all BBOX1 antibodies

Published Data

Fig. 1 Immunoblot analysis showing expression levels of FAO activators PGC-1α and BBOX1, and fatty acid synthesis enzymes FASN, ACC1, ACC2 and pACC1/2 in a panel of TN and RP human cell lines.

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

6H3

Antibody Isotype

IgG1, κ

Application

WB, ELISA, IHC

Basic Information

Immunogen

BBOX1 (NP_003977, 278 a.a. ~ 387 a.a) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IHC	3 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1

Introduction

This gene encodes gamma butyrobetaine hydroxylase which catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. [provided by RefSeq]

Entrez Gene ID

8424

UniProt ID

O75936

Alternative Names

BBH; BBOX; G-BBH; gamma-BBH

Function

Catalyzes the formation of L-carnitine from gamma-butyrobetaine.

Biological Process

Carnitine biosynthetic process Source: UniProtKB

Cellular Location

Cytoplasm

References

Liao, C., Zhang, Y., Fan, C., Herring, L. E., Liu, J., Locasale, J. W., ... & Zhang, Q. (2021). Abstract PD15-10: Identification of BBOX1 as a therapeutic target in triple-negative breast cancer.

Liao, C., & Zhang, Q. (2020). BBOX1 promotes triple-negative breast cancer progression by controlling IP3R3 stability. Molecular & Cellular Oncology, 7(6), 1813526.

Liao, C., Zhang, Y., Fan, C., Herring, L. E., Liu, J., Locasale, J. W., ... & Zhang, Q. (2020). Identification of BBOX1 as a therapeutic target in triple-negative breast cancer. Cancer discovery, 10(11), 1706-1721.

Zhou, G., Cao, Y., Xin, Y., Song, Y., & Jin, H. (2018). Alternative polyadenylation and polymorphisms of 3'untranslated regions of bovine BBOX1 gene. Czech Journal of Animal Science, 63(5), 188-194.

Lee, H., Kim, H. K., Kwon, J. T., Park, S., Park, H. J., Kim, S. K., ... & Kim, H. J. (2018). BBOX1 is down-regulated in maternal immune-activated mice and implicated in genetic susceptibility to human schizophrenia. Psychiatry research, 259, 197-202.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-BBOX1 Recombinant Antibody (CBYY-0233)

Mouse Anti-BBOX1 Recombinant Antibody (CBYY-0250)

Mouse Anti-BBOX1 Recombinant Antibody (CBYY-0234)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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