Mouse Anti-BBOX1 Recombinant Antibody (CBYY-0234) (CBMAB-0235-YY)

This product is mouse antibody that recognizes BBOX1. The antibody CBYY-0234 can be used for immunoassay techniques such as: IHC-P, WB
See all BBOX1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

CBYY-0234

Antibody Isotype

IgG1

Application

WB, IHC

Basic Information

Immunogen

Full length human recombinant protein of human BBovineX1 produced in HEK293T cell

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:4,000
IHC	1:150

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1

Introduction

This gene encodes gamma butyrobetaine hydroxylase which catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation.

Entrez Gene ID

8424

UniProt ID

O75936

Alternative Names

Gamma-Butyrobetaine Hydroxylase 1; Butyrobetaine (Gamma), 2-Oxoglutarate Dioxygenase (Gamma-Butyrobetaine Hydroxylase) 1; Gamma-BBH; BBovineX; BBH; Gamma-Butyrobetaine,2-Oxoglutarate Dioxygenase 1;

Function

Catalyzes the formation of L-carnitine from gamma-butyrobetaine.

Biological Process

Carnitine biosynthetic process Source: UniProtKB

Cellular Location

Cytoplasm

References

Liao, C., Zhang, Y., Fan, C., Herring, L. E., Liu, J., Locasale, J. W., ... & Zhang, Q. (2021). Abstract PD15-10: Identification of BBOX1 as a therapeutic target in triple-negative breast cancer.

Liao, C., & Zhang, Q. (2020). BBOX1 promotes triple-negative breast cancer progression by controlling IP3R3 stability. Molecular & Cellular Oncology, 7(6), 1813526.

Liao, C., Zhang, Y., Fan, C., Herring, L. E., Liu, J., Locasale, J. W., ... & Zhang, Q. (2020). Identification of BBOX1 as a therapeutic target in triple-negative breast cancer. Cancer discovery, 10(11), 1706-1721.

Zhou, G., Cao, Y., Xin, Y., Song, Y., & Jin, H. (2018). Alternative polyadenylation and polymorphisms of 3'untranslated regions of bovine BBOX1 gene. Czech Journal of Animal Science, 63(5), 188-194.

Lee, H., Kim, H. K., Kwon, J. T., Park, S., Park, H. J., Kim, S. K., ... & Kim, H. J. (2018). BBOX1 is down-regulated in maternal immune-activated mice and implicated in genetic susceptibility to human schizophrenia. Psychiatry research, 259, 197-202.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-BBOX1 Recombinant Antibody (6H3)

Mouse Anti-BBOX1 Recombinant Antibody (CBYY-0233)

Mouse Anti-BBOX1 Recombinant Antibody (CBYY-0250)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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