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Mouse Anti-BCL7B Recombinant Antibody (4G1) (CBMAB-A0741-LY)

The product is antibody recognizes BCL7B. The antibody 4G1 immunoassay techniques such as: WB, ELISA.
See all BCL7B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4G1
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
BCL7B (NP_001698, 124 a.a. ~ 202 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
B-cell CLL/lymphoma 7B
Introduction
The protein encoded by this gene contains a region that is highly similar to the N-terminal segment of BCL7A protein. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. The function of this gene has not yet been determined. [provided by RefSeq]
Entrez Gene ID
9275
UniProt ID
Q9BQE9
Function
Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233).
Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233).
May play a role in lung tumor development or progression (By similarity).
Biological Process
Apoptotic process Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Wnt signaling pathway Source: UniProtKB-KW
Involvement in disease
BCL7B is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of BCL7B may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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