Mouse Anti-BCL7B Recombinant Antibody (6D2) (CBMAB-A0742-LY)

Name: Mouse Anti-BCL7B Recombinant Antibody (6D2)
SKU: CBMAB-A0742-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

6D2

Application

WB, ELISA

Immunogen

BCL7B (NP_001698, 124 a.a. ~ 202 a.a) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

B-cell CLL/lymphoma 7B

Introduction

The protein encoded by this gene contains a region that is highly similar to the N-terminal segment of BCL7A protein. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. The function of this gene has not yet been determined. [provided by RefSeq]

Entrez Gene ID

9275

UniProt ID

Q9BQE9

Function

Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233).
Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233).
May play a role in lung tumor development or progression (By similarity).

Biological Process

Apoptotic process Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Wnt signaling pathway Source: UniProtKB-KW

Involvement in disease

BCL7B is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of BCL7B may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

Yang, D., Gu, X., Li, C., Shi, J., Chen, Y., Dong, M., & Zhang, Z. (2021). BCL7B is a potential novel diagnosis and prognosis biomarker for sarcomas using bioinformatics analysis. Medicine, 100(28).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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