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Mouse Anti-BDP1 Recombinant Antibody (CBYY-0479) (CBMAB-0482-YY)

This product is mouse antibody that recognizes BDP1. The antibody CBYY-0479 can be used for immunoassay techniques such as: WB, IP, IF, ELISA
See all BDP1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human, Pig
Clone
CBYY-0479
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 435-454 near the C-terminus of BDP1 of human origin.
Host Species
Mouse
Specificity
Mouse, Rat, Human, Pig
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
B Double Prime 1, Subunit Of RNA Polymerase III Transcription Initiation Factor IIIB
Introduction
The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.
Entrez Gene ID
Human55814
Mouse544971
Rat294687
UniProt ID
HumanA6H8Y1
MouseQ571C7
RatD3ZDI4
Alternative Names
B Double Prime 1, Subunit Of RNA Polymerase III Transcription Initiation Factor IIIB; TATA Bovinex Binding Protein (TBP)-Associated Factor, RNA Polymerase III, GTF3B Subunit 1; Transcription Factor-Like Nuclear Regulator; Transcription Factor IIIB 150; TFIIIB150; TFNR; RNA Polymerase III Transcription Initiation Factor B; Transcription Factor TFIIIB Component B Homolog;
Function
General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site.
Biological Process
RNA polymerase III preinitiation complex assembly Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Deafness, autosomal recessive, 112 (DFNB112): A form of non-syndromic, sensorineural deafness characterized by postlingual progressive hearing impairment. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
PTM
Phosphorylated by CSNK2A1 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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