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Mouse Anti-BICC1 Recombinant Antibody (CBYY-0556) (CBMAB-0559-YY)

This product is mouse antibody that recognizes BICC1. The antibody CBYY-0556 can be used for immunoassay techniques such as: WB, IP, IF, ELISA
See all BICC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-0556
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 243-480 mapping within an internal region of BICC1 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BicC Family RNA Binding Protein 1
Introduction
This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product. [provided by RefSeq, Apr 2009]
Entrez Gene ID
80114
UniProt ID
Q9H694
Alternative Names
BicC Family RNA Binding Protein 1; Bicaudal C Homolog 1 (Drosophila); FGFR2-BICC1 Fusion Kinase Protein; Protein Bicaudal C Homolog 1; Bicaudal C Homolog 1; CYSRD; Bic-C; BICC;
Function
Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.
Biological Process
Determination of left/right symmetry Source: Ensembl
Heart development Source: Ensembl
Kidney development Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Renal dysplasia, cystic (CYSRD): An anomaly of the kidney characterized by numerous renal cysts and apparent disorder of differentiation of the renal parenchyma. Kidney of affected individuals lack the normal renal bean shape, and the collection drainage system. The cystic, dysplastic kidney contains undifferentiated mesenchyme, cartilaginous tissue, and immature collecting ducts.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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