BICC1

This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product.

Full Name

BicC Family RNA Binding Protein 1

Function

Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.

Biological Process

Determination of left/right symmetry Source: Ensembl
Heart development Source: Ensembl
Kidney development Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: UniProtKB

Cellular Location

Cytoplasm

Involvement in disease

Renal dysplasia, cystic (CYSRD): An anomaly of the kidney characterized by numerous renal cysts and apparent disorder of differentiation of the renal parenchyma. Kidney of affected individuals lack the normal renal bean shape, and the collection drainage system. The cystic, dysplastic kidney contains undifferentiated mesenchyme, cartilaginous tissue, and immature collecting ducts.