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Mouse Anti-BMPR1B Recombinant Antibody (CBYY-0687) (CBMAB-0690-YY)

This product is mouse antibody that recognizes BMPR1B. The antibody CBYY-0687 can be used for immunoassay techniques such as: WB, IHC-P, ICC
See all BMPR1B antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Human
Clone
CBYY-0687
Antibody Isotype
IgG2a
Application
WB, IHC-P, ICC

Basic Information

Specificity
Mouse, Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Bone Morphogenetic Protein Receptor Type 1B
Introduction
This gene encodes a member of the Bovinene morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral Bovinene formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of aBovineut 50-55 kD and type II receptors of aBovineut 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforMouse have been found for this gene. [provided by RefSeq, Feb 2012]
Entrez Gene ID
Human658
Mouse12167
UniProt ID
HumanO00238
MouseP36898
Alternative Names
Bovinene Morphogenetic Protein Receptor Type 1B; Bovinene Morphogenetic Protein Receptor, Type IB; BMP Type-1B Receptor; EC 2.7.11.30; BMPR-1B; Bovinene Morphogenetic Protein Receptor Type-1B; Serine/Threonine Receptor Kinase; Activin Receptor-Like Kinase 6; CDw293 Antigen;
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.
Biological Process
BMP signaling pathway Source: BHF-UCL
Cartilage condensation Source: UniProtKB
Cellular response to BMP stimulus Source: BHF-UCL
Cellular response to growth factor stimulus Source: GO_Central
Chondrocyte development Source: AgBase
Dorsal/ventral pattern formation Source: GO_Central
Endochondral bone morphogenesis Source: AgBase
Eye development Source: UniProtKB
Inflammatory response Source: Ensembl
Limb morphogenesis Source: UniProtKB
Negative regulation of BMP signaling pathway Source: Reactome
Negative regulation of chondrocyte proliferation Source: AgBase
Osteoblast differentiation Source: Ensembl
Ovarian cumulus expansion Source: UniProtKB
Ovulation cycle Source: UniProtKB
Positive regulation of BMP signaling pathway Source: Reactome
Positive regulation of bone mineralization Source: BHF-UCL
Positive regulation of cartilage development Source: AgBase
Positive regulation of cell differentiation Source: UniProtKB
Positive regulation of chondrocyte differentiation Source: UniProtKB
Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
Positive regulation of osteoblast differentiation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Protein phosphorylation Source: HGNC-UCL
Proteoglycan biosynthetic process Source: AgBase
Retina development in camera-type eye Source: Ensembl
Retinal ganglion cell axon guidance Source: Ensembl
Skeletal system development Source: UniProtKB
Cellular Location
Cell membrane; Membrane
Involvement in disease
Acromesomelic dysplasia, Demirhan type (AMDD): A form of chondrodysplasia. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDD inheritance is autosomal recessive.
Brachydactyly A2 (BDA2): A form of brachydactyly. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. In brachydactyly type A2 shortening of the middle phalanges is confined to the index finger and the second toe, all other digits being more or less normal. Because of a rhomboid or triangular shape of the affected middle phalanx, the end of the second finger usually deviates radially.
Brachydactyly A1, D (BDA1D): A form of brachydactyly type A1. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. Brachydactyly type A1 is characterized by middle phalanges of all the digits rudimentary or fused with the terminal phalanges. The proximal phalanges of the thumbs and big toes are short. BDA1D inheritance is autosomal dominant.
Topology
Extracellular: 14-126 aa
Helical: 127-148 aa
Cytoplasmic: 149-502 aa

Chinedu, O., Tonassé, W. V., Albuquerque, D. M., de Farias Domingos, I., da Silva Araújo, A., Bezerra, M. A. C., ... & Dos Santos, M. N. N. (2021). Polymorphisms in the heme oxygenase-1 and bone morphogenetic protein receptor type 1b genes and estimated glomerular filtration rate in Brazilian sickle cell anemia patients. Hematology, Transfusion and Cell Therapy, 43(2), 165-170.

ÃelikeloÄlu, K., Tekerli, M., ErdoÄan, M., Koçak, S., Hacan, Ö., & Bozkurt, Z. (2021). An investigation of the effects of BMPR1B, BMP15, and GDF9 genes on litter size in Ramlıç and DaÄlıç sheep. Archives Animal Breeding, 64(1), 223-223.

Pourali Dogaheh, S., Mirhoseini, S. Z., Tufarelli, V., Hossein-Zadeh, N. G., Badbarin, S., Colonna, M. A., ... & Selvaggi, M. (2020). Investigating the Polymorphism of Bone Morphogenetic Protein Receptor-1B (BMPR1B) Gene in Markhoz Goat Breed. Animals, 10(9), 1582.

Alshangiti, A. M., Wyatt, S. L., McCarthy, E., Collins, L. M., Hegarty, S. V., Sullivan, A. M., & O’Keeffe, G. W. (2020). Association of distinct type 1 bone morphogenetic protein receptors with different molecular pathways and survival outcomes in neuroblastoma. Neuronal signaling, 4(1), NS20200006.

Wu, Y. J., Lee, Y. N., Wu, T. W., Chou, C. L., & Wang, L. Y. (2019). Common Genetic Variants on Bone Morphogenetic Protein Receptor Type IB (BMPR1B) Gene Are Predictive for Carotid Intima-Media Thickness. Circulation Journal, 83(4), 749-756.

Yao, Y., Reheman, A., Xu, Y., & Li, Q. (2019). miR-125b contributes to ovarian granulosa cell apoptosis through targeting BMPR1B, a major gene for sheep prolificacy. Reproductive Sciences, 26(2), 295-305.

Yao, Y., Niu, J., Sizhu, S., Li, B., Chen, Y., Li, R., ... & Xu, Y. (2018). microRNA-125b regulates apoptosis by targeting bone morphogenetic protein receptor 1B in yak granulosa cells. DNA and cell biology, 37(11), 878-887.

Zhou, S., Yu, H., Zhao, X., Cai, B., Ding, Q., Huang, Y., ... & Wang, X. (2018). Generation of gene-edited sheep with a defined Booroola fecundity gene (FecBB) mutation in bone morphogenetic protein receptor type 1B (BMPR1B) via clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) 9. Reproduction, Fertility and Development, 30(12), 1616-1621.

Kumari, R., Dayal, S., Kumar, S., Chandran, P. C., & Dey, A. (2017). Genetic polymorphism of bone morphogenetic protein receptor type-1 (BMPR1B) gene in crossbred does of Bihar. Indian Journal of Animal Sciences, 87, 4.

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For research use only. Not intended for any clinical use.

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